PINK1 antibody (Internal Region)
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- Target See all PINK1 Antibodies
- PINK1 (PTEN Induced Putative Kinase 1 (PINK1))
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Binding Specificity
- AA 350-500, Internal Region
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Reactivity
- Human, Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PINK1 antibody is un-conjugated
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Application
- Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Specificity
- Reacts with human and mouse PINK1 protein
- Purification
- Antigen affinity purified
- Immunogen
- A genomic peptide made to an internal region of the human PINK1 protein (within residues 350-500).
- Isotype
- IgG
- Top Product
- Discover our top product PINK1 Primary Antibody
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- Application Notes
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Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
ICC/IF1:500-1:1000, IHC1:100, IHC-P 1:100 - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1.17 mg/mL
- Buffer
- PBS, Sodium azide 0.05 %
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Short term storage at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.
- Expiry Date
- 6 months
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- Target
- PINK1 (PTEN Induced Putative Kinase 1 (PINK1))
- Alternative Name
- PINK1 (PINK1 Products)
- Synonyms
- BEST:GH23468 antibody, CG4523 antibody, Dmel\\CG4523 antibody, PINK antibody, PINK1 antibody, dPINK1 antibody, dPink1 antibody, pink1 antibody, wu:fc39e12 antibody, zgc:101729 antibody, BRPK antibody, PARK6 antibody, 1190006F07Rik antibody, AU042772 antibody, AW557854 antibody, mFLJ00387 antibody, PTEN-induced putative kinase 1 antibody, PTEN induced putative kinase 1 antibody, Pink1 antibody, PINK1 antibody, pink1 antibody
- Background
- PTEN induced putative kinase 1 (Pink1) was first discovered when researching the PTEN signaling pathway, thus Pink1 is also involved in many human cancers.It is found in the mitochondria and its homozygous C-terminus mutation has been implicated in the early development of Parkinson's disease. It protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2.
- Gene ID
- 65018
- UniProt
- Q9BXM7
- Pathways
- Autophagy
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