EPOR antibody (Extracellular Domain)

Catalog No. ABIN1819428

Product Details anti-EPOR Antibody

Target: EPOR (Erythropoietin Receptor (EPOR))

Binding Specificity: Extracellular Domain

Reactivity: Human, Mouse

Host: Sheep

Clonality: Polyclonal

Conjugate: This EPOR antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Specificity: Recognizes Erythropoietin Receptor (EPOR), a type I transmembrane protein and member of the type I cytokine receptor family, expressed by erythroid cells and erythroid progenitor cells, which acts as a receptor for erythropoietin (EPO) to mediate erythroblast proliferation and differentiation, and maintain progenitor survival. Binding of EPO to EPOR, results in the dimerization of the EPOR and the triggering of the JAK2/STAT5 signaling cascade, and in some cell types activation of STAT1 and STAT3. Several isoforms of EPOR exist: EPOR-F, EPOR-S and EPOR-T, and a functional EPOR is found on endothelial cells and cardiomyocytes within the cardiovascular system, suggesting a role in cardiac function. AHP1825 has been shown to block Iodine125 labeled erythropoietin ligand binding using erythroleukemia cell line TF-1 with 3000 EPOR/cell in neutralization studies, see for details. AHP1825 is reported as suitable for use in immunocytochemistry. AHP1825 has been reported for use in functional studies. Removal of Sodium Azide is recommended prior to use in functional assays. The recommended concentration for functional assays is 500 μg/mL.

Purification: Affinity purified

Immunogen: Partial cDNA of the extracellular domain of human EpoR expressed as a GST fusion protein in E. coli.

Type of Immunogen: Fusion protein

Isotype: IgG

Application Details

Application Notes: Approved: ELISA, IP (10 μg/mL), WB (10 μg/mL)

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze.

Storage: 4 °C

Storage Comment: Store at 4°C. Do not freeze.

Target Details for EPOR

Target: EPOR (Erythropoietin Receptor (EPOR))

Alternative Name: EPOR / EPO Receptor (EPOR Products)

Synonyms: EPOR antibody, epor antibody, EPO-R antibody, erythropoietin receptor antibody, erythropoietin receptor L homeolog antibody, EPOR antibody, epor antibody, Epor antibody, epor.L antibody

Background: Name/Gene ID: EPOR
Family: Cytokine Receptor

Synonyms: EPOR, EPO Receptor, EPO-R, Erythropoietin receptor

Gene ID: 2057

Pathways: JAK-STAT Signaling