LAT antibody

Catalog No. ABIN1819430

Product Details anti-LAT Antibody

Target: LAT (Linker For Activation of T Cells (LAT))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LAT antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: Recognizes human LAT1 (L-type amino acid transporter 1), a heterodimeric Na+-independent amino acid transporter protein and member of the amino acid-polyamine-organocation (APC) superfamily, involved in the high-affinity transport of large neutral amino acids, in association with SLC3A2/4F2hc. LAT1 is highly expressed in the brain and is involved in the transport of L-DOPA across the blood-brain barrier, in brain neurogenesis, and acts as a mediator of L-leucine transport across the inner blood-retinal barrier. LAT1 is involved in the cell membrane transport of the thyroid hormones triiodothyronine (T3) and thyroxine (T4) in the placenta, and is the foremost transporter of tyrosine in fibroblasts.

Purification: Affinity purified

Immunogen: Keyhole limpet hemocyanin (KLH) conjugated synthetic peptide C-RHRKPEL, representing a portion of human LAT1.

Type of Immunogen: Synthetic peptide

Isotype: IgG

Application Details

Application Notes: Approved: IHC, IHC-P (5 μg/mL)

Usage: The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS

Preservative: Azide free

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze-thaw cycles.

Target Details for LAT

Target: LAT (Linker For Activation of T Cells (LAT))

Alternative Name: LAT1 / LAT (LAT Products)

Synonyms: LAT antibody, lat antibody, LAT1 antibody, pp36 antibody, linker for activation of T-cells antibody, linker for activation of T cells antibody, LAT antibody, lat antibody, Lat antibody

Background: Name/Gene ID: LAT

Synonyms: LAT, p36-38, Pp36, LAT1

Gene ID: 27040

UniProt: O43561

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway