Western Blotting (WB), Flow Cytometry (FACS), Functional Studies (Func)
Specificity
TRAIL is a cytotoxic protein closely related to Fas (CD95), which induces extensive apoptosis in a range of cell types. TRAIL induces apoptosis via the receptors DR4 and DR5. Most normal tissues are resistant to TRAIL induced apoptosis due to their expression of decoy receptors, DcR1 and DcR2, which antagonize TRAIL activity. TRAIL is expressed by cell lines, activated lymphocytes and on syncytiotrophoblast cells in first trimester pregnancy. This antibody neutralizes TRAIL activity.
Purification
Protein A purified
Immunogen
Recombinant human CD253 (TRAIL) aa 95-281. ImmunogenType: Recombinant protein