NQO1 antibody

Catalog No. ABIN1819945

Product Details anti-NQO1 Antibody

Target: NQO1 (NAD(P)H Dehydrogenase, Quinone 1 (NQO1))

Reactivity: Human, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This NQO1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificity: Recognizes human NQO1 (NAD(P)H: quinone oxidoreductase 1), a 31kD cytosolic flavoenzyme and member of the NAD(P)H dehydrogenase (quinone) family, involved in detoxification, which catalyzes the two-electron reduction of quinones to hydroquinones. NQO1 is expressed in a wide range of tissues and is overexpressed in many human tumors including lung, brain, liver, colon and breast. The ability of NQO1 to bioactivate anti-tumor quinones including mitomycin C and diaziquone, has become a focus area for chemotherapeutic studies. Mutations in the NQO1 gene are associated with an increased risk of certain cancers, and an increased risk of leukaemia has been associated with diminished NQO1 activity and the NQO1 *2 allele. Clone A180 detects endogenous levels of total NQO1, and does not cross-react with NQO2. Clone A180 is reported as suitable for use in immunofluorescence studies.

No Cross-Reactivity: Mouse (Murine)

Purification: Protein G purified

Immunogen: Purified recombinant human NQO1.

Clone: A180

Isotype: IgG1

Application Details

Application Notes: Approved: IHC, IHC-P, IP, WB (1:100 - 1:1000)

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C,-20 °C

Storage Comment: 4°C or -20°C, Avoid freeze-thaw cycles.

Target Details for NQO1

Target: NQO1 (NAD(P)H Dehydrogenase, Quinone 1 (NQO1))

Alternative Name: NQO1 (NQO1 Products)

Synonyms: zgc:77191 antibody, wu:fb63c10 antibody, nqo1 antibody, DHQU antibody, DIA4 antibody, DTD antibody, NMOR1 antibody, NMORI antibody, QR1 antibody, Dia4 antibody, AV001255 antibody, Dtd antibody, Nmo-1 antibody, Nmo1 antibody, Nmor1 antibody, Ox-1 antibody, Ox1 antibody, Qr1 antibody, NADPH-d antibody, NAD(P)H dehydrogenase, quinone 1 antibody, NAD(P)H quinone dehydrogenase 1 antibody, NAD(P)H dehydrogenase, quinone 1 L homeolog antibody, nqo1 antibody, NQO1 antibody, Bpet2092 antibody, nqo1.L antibody, Nqo1 antibody

Background: Name/Gene ID: NQO1

Synonyms: NQO1, Azoreductase, DHQU, DT-diaphorase, Dioxin-inducible 1, DIA4, Diaphorase-4, NAD(P)H:quinone oxireductase, Phylloquinone reductase, QR1, Menadione reductase, NMOR1, NMORI, DTD, Quinone reductase 1

Gene ID: 1728

UniProt: P15559