CHUK antibody (conserved Helix-Loop-Helix Ubiquitous Kinase) (AA 84-112)

Details for Product anti-CHUK Antibody No. ABIN1881203, Supplier: Log in to see
Antigen
  • ikk
  • ikk1
  • ikka
  • ikkalpha
  • CHUK
  • IKBKA
  • IKK-alpha
  • IKK1
  • IKKA
  • NFKBIKA
  • TCF16
  • AI256658
  • Chuk1
  • Fbx24
  • Fbxo24
  • Ikka
  • zgc:56539
  • conserved helix-loop-helix ubiquitous kinase S homeolog
  • conserved helix-loop-helix ubiquitous kinase
  • chuk.S
  • CHUK
  • Chuk
  • chuk
Alternatives
anti-Human CHUK antibody for Western Blotting
Epitope
AA 84-112, N-Term
44
35
15
15
15
14
11
10
10
9
8
8
8
7
7
7
7
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5
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
327
143
111
12
11
10
7
6
5
5
4
2
Host
Rabbit
276
53
13
1
Clonality (Clone)
Polyclonal ()
Conjugate
This CHUK antibody is un-conjugated
14
10
10
8
8
8
2
2
2
2
2
2
2
2
2
2
2
Application
Western Blotting (WB)
304
155
114
48
41
38
27
25
11
9
4
3
2
2
1
Options
Supplier
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Supplier Product No.
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Immunogen This CHUK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 84-112 amino acids from the N-terminal region of human CHUK.
Clone RB41290
Predicted Reactivity Cow (Bovine),Chicken,Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Plasmids, Primers & others Plasmids, Primers & others CHUK products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name CHUK (CHUK Antibody Abstract)
Background This gene encodes a member of the serine/threonine protein kinase family. The encoded protein, a component of a cytokine-activated protein complex that is an inhibitor of the essential transcription factor NF-kappa-B complex, phosphorylates sites that trigger the degradation of the inhibitor via the ubiquination pathway, thereby activating the transcription factor.

Synonyms: CHUK, IKKA, TCF16, Inhibitor of nuclear factor kappa-B kinase subunit alpha, Conserved helix-loop-helix ubiquitous kinase, I-kappa-B kinase 1, Nuclear factor NF-kappa-B inhibitor kinase alpha, Transcription factor 16
NCBI Accession NP_001269
UniProt O15111
Pathways PI3K-Akt Signaling, NF-kappaB Signaling, RTK Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades
Application Notes WB: 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
Western Blotting (WB) image for anti-conserved Helix-Loop-Helix Ubiquitous Kinase (CHUK) (AA 84-112), (N-Term) antibody (ABIN1881203) CHUK Antibody (N-term) (ABIN1881203) western blot analysis in Jurkat cell line lysate...
Product cited in: Lahtela, Nousiainen, Stefanovic, Tallila, Viskari, Karikoski, Gentile, Saloranta, Varilo, Salonen, Kestilä: "Mutant CHUK and severe fetal encasement malformation." in: The New England journal of medicine, Vol. 363, Issue 17, pp. 1631-7, 2010 (PubMed).

Gouin, Adib-Conquy, Balestrino, Nahori, Villiers, Colland, Dramsi, Dussurget, Cossart: "The Listeria monocytogenes InlC protein interferes with innate immune responses by targeting the I{kappa}B kinase subunit IKK{alpha}." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 40, pp. 17333-8, 2010 (PubMed).

Cummins, Oliver, Lenihan, Fitzpatrick, Bruning, Scholz, Slattery, Leonard, McLoughlin, Taylor: "NF-κB links CO2 sensing to innate immunity and inflammation in mammalian cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 7, pp. 4439-45, 2010 (PubMed).

Li, Morgan, Choksi, Zhang, Kim, Liu: "MicroRNAs modulate the noncanonical transcription factor NF-kappaB pathway by regulating expression of the kinase IKKalpha during macrophage differentiation." in: Nature immunology, Vol. 11, Issue 9, pp. 799-805, 2010 (PubMed).

Rotman, Koh, Zmuda, Kleiner, Liang: "The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease." in: Hepatology (Baltimore, Md.), Vol. 52, Issue 3, pp. 894-903, 2010 (PubMed).

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