XRCC4 antibody (AA 216-269)

Catalog No. ABIN1886206

Product Details anti-XRCC4 Antibody

Target: XRCC4 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 (XRCC4))

Binding Specificity: AA 216-269

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This XRCC4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Purification: Purified by antigen-affinity chromatography.

Immunogen: Synthetic peptide contain a sequence corresponding to a region within amino acids 216 and 269 (Q13426) of XRCC4

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.250
Immunofluorescence: 1.100-1.200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for XRCC4

Target: XRCC4 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 (XRCC4))

Alternative Name: XRCC4 (XRCC4 Products)

Synonyms: zgc:73312 antibody, MGC81443 antibody, homolog of human DNA ligase iv-binding protein XRCC4 antibody, 2310057B22Rik antibody, AW413319 antibody, AW545101 antibody, X-ray repair cross complementing 4 antibody, X-ray repair complementing defective repair in Chinese hamster cells 4 antibody, X-ray repair complementing defective repair in Chinese hamster cells 4 L homeolog antibody, DNA ligase IV-binding protein antibody, XRCC4 antibody, xrcc4 antibody, xrcc4.L antibody, Xrcc4 antibody

Background: The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events.The non-homologous end-joining pathway is required both for normal development and for suppression of tumors.This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes.Alternative transcription initiation and alternative splicing generates several transcript variants.[provided by RefSeq]

Molecular Weight: 38 kDa

Gene ID: 7518

NCBI Accession: NP_071801, NM_022406

Pathways: DNA Damage Repair, Production of Molecular Mediator of Immune Response