PCBP2 antibody (AA 299-362)

Catalog No. ABIN1886337

Product Details anti-PCBP2 Antibody

Target: PCBP2 (Poly(rC) Binding Protein 2 (PCBP2))

Binding Specificity: AA 299-362

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCBP2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Purification: Purified by antigen-affinity chromatography.

Immunogen: Synthetic peptide contain a sequence corresponding to a region within amino acids 299 and 362 of PCBP2

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunofluorescence: 1.100-1.200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for PCBP2

Target: PCBP2 (Poly(rC) Binding Protein 2 (PCBP2))

Alternative Name: PCBP2 (PCBP2 Products)

Synonyms: HNRNPE2 antibody, HNRPE2 antibody, hnRNP-E2 antibody, AW412548 antibody, Hnrpx antibody, alphaCP-2 antibody, PCBP3 antibody, fb36h02 antibody, wu:fb36h02 antibody, zgc:55964 antibody, PCBP2 antibody, poly(rC) binding protein 2 antibody, poly(rC) binding protein 2 L homeolog antibody, PCBP2 antibody, Pcbp2 antibody, pcbp2 antibody, pcbp2.L antibody

Background: The protein encoded by this gene appears to be multifunctional.Along with PCBP-1 and hnRNPK, it is one of the major cellular poly(rC)-binding proteins.The encoded protein contains three K-homologous (KH) domains which may be involved in RNA binding.Together with PCBP-1, this protein also functions as a translational coactivator of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES, promoting poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure.It has also been implicated in translational control of the 15-lipoxygenase mRNA, human papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA.The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.This multiexon structural mRNA is thought to be retrotransposed to generate PCBP-1, an intronless gene with functions similar to that of PCBP2.This gene and PCBP-1 have paralogous genes (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes.Thsi gene also has two processed pseudogenes (PCBP2P1 and PCBP2P2).Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq]
Synonyms: HNRPE2, MGC110998, hnRNP-E2

Molecular Weight: 38 kDa

Gene ID: 5094

NCBI Accession: NM_031989, NP_114366