HLA-DMA antibody (AA 52-255)

Catalog No. ABIN1886528

Product Details anti-HLA-DMA Antibody

Target: HLA-DMA (Major Histocompatibility Complex, Class II, DM alpha (HLA-DMA))

Binding Specificity: AA 52-255

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HLA-DMA antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 52 and 255 of HLA-DMA

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.250

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 20 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for HLA-DMA

Target: HLA-DMA (Major Histocompatibility Complex, Class II, DM alpha (HLA-DMA))

Alternative Name: HLA-DMA (HLA-DMA Products)

Synonyms: RT1.Ma antibody, RT1.DMa antibody, HLA-DMA antibody, H-2Ma antibody, H2-Ma antibody, D6S222E antibody, DMA antibody, HLADM antibody, RING6 antibody, RT1 class II, locus DMa antibody, SLA-DM alpha chain antibody, major histocompatibility complex, class II, DM alpha antibody, histocompatibility 2, class II, locus DMa antibody, RT1-DMa antibody, SLA-DMA antibody, DLA-DMA antibody, H2-DMa antibody, HLA-DMA antibody

Background: HLA-DMA belongs to the HLA class II alpha chain paralogues.This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane.It is located in intracellular vesicles.DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site.Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages).The alpha chain is approximately 33-35 kDa and its gene contains 5 exons.Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail.[provided by RefSeq]

Molecular Weight: 29 kDa

Gene ID: 3108

Pathways: Cancer Immune Checkpoints