SCO1 antibody (Center)

Catalog No. ABIN1887510

Product Details anti-SCO1 Antibody

Target: SCO1 (SCO1 Cytochrome C Oxidase Assembly Protein (SCO1))

Binding Specificity: Center

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SCO1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogen: 14 amino acid peptide from near the center of human SCO1.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for SCO1

Target: SCO1 (SCO1 Cytochrome C Oxidase Assembly Protein (SCO1))

Alternative Name: SCO1 (SCO1 Products)

Synonyms: SCOD1 antibody, 2610001C07Rik antibody, D11Bwg1310e antibody, SCO1 antibody, RGD1559538 antibody, SCO1, cytochrome c oxidase assembly protein antibody, SCO1 cytochrome c oxidase assembly protein antibody, SCO1 antibody, Sco1 antibody, sco1 antibody

Background: Synthesis of cytochrome c oxidase 1 was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane.Like their yeast homologs, the function of both SCO1 and SCO2 are dependent on copper ion binding.Mutations in either gene can lead to cytochrome c oxidase respiratory chain defects, with a missense mutation in human SCO1 (P174L) associated with a fatal neonatal hepatopathy when the second allele is also non-functional, suggesting the pathology is due to loss of function.It has been suggested that this mutation alters the SCO1 affinity for the copper (I) ion, thus impairing the efficiency of copper transfer to the cytochrome c oxidase.At least two isoforms of SCO1 are known to exist and both are recognized by the SCO1 antibody.This SCO1 antibody has no cross-reactivity to SCO2.
Synonyms: SCO1, Synthesis of cytochrome c oxidase 1, cytochrome oxidase deficient homolog 1

UniProt: O75880

Pathways: Sensory Perception of Sound, Transition Metal Ion Homeostasis, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity