ATG101 antibody (Center)

Catalog No. ABIN1887613

Product Details anti-ATG101 Antibody

Target: ATG101 (C12orf44) (Chromosome 12 Open Reading Frame 44 (C12orf44))

Binding Specificity: Center

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATG101 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Affinity chromatography purified via peptide column

Immunogen: 16 amino acid peptide near the center of human ATG101.

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handling Advice: Avoid freezing and thawing repeatly.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Target Details for ATG101

Target: ATG101 (C12orf44) (Chromosome 12 Open Reading Frame 44 (C12orf44))

Alternative Name: ATG101 (C12orf44 Products)

Synonyms: ATG101 antibody, C12orf44 antibody, AA407441 antibody, AU022967 antibody, Atg101 antibody, atg101 antibody, im:6904812 antibody, autophagy related 101 antibody, ATG101 antibody, Atg101 antibody, atg101 antibody

Background: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells.It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components.This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein ATG1.ATG101 is a recently discovered protein that stabilizes ATG13, another autophagy protein that forms a complex with the mammalian homologs of ATG1, ULK1 and ULK2, and with FIP200.This complex is a target of TOR phosphorylation under normal conditions, inhibition of TOR by rapamycin or leucine deprivation leads to dephosphorylation of ATG13, ULK1 and ULK2, which then leads to autophagy.ATG101 also interacts with ULK1 and is essential for autophagy.
Synonyms: Autophagy-related protein 101, ATG13-interacting protein

NCBI Accession: NP_001092143

Pathways: Autophagy