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ATG101 antibody (Center)

C12orf44 Reactivity: Human, Mouse, Rat WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1887613
  • Target See all ATG101 (C12orf44) Antibodies
    ATG101 (C12orf44) (Chromosome 12 Open Reading Frame 44 (C12orf44))
    Binding Specificity
    • 15
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Center
    Reactivity
    • 22
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    Human, Mouse, Rat
    Host
    • 22
    Rabbit
    Clonality
    • 22
    Polyclonal
    Conjugate
    • 8
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ATG101 antibody is un-conjugated
    Application
    • 22
    • 13
    • 13
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Purification
    Affinity chromatography purified via peptide column
    Immunogen
    16 amino acid peptide near the center of human ATG101.
    Top Product
    Discover our top product C12orf44 Primary Antibody
  • Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
    Handling Advice
    Avoid freezing and thawing repeatly.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 4 °C for short term use.Store at -20 °C for long term preservation.
  • Target
    ATG101 (C12orf44) (Chromosome 12 Open Reading Frame 44 (C12orf44))
    Alternative Name
    ATG101 (C12orf44 Products)
    Synonyms
    ATG101 antibody, C12orf44 antibody, AA407441 antibody, AU022967 antibody, Atg101 antibody, atg101 antibody, im:6904812 antibody, autophagy related 101 antibody, ATG101 antibody, Atg101 antibody, atg101 antibody
    Background
    Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells.It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components.This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein ATG1.ATG101 is a recently discovered protein that stabilizes ATG13, another autophagy protein that forms a complex with the mammalian homologs of ATG1, ULK1 and ULK2, and with FIP200.This complex is a target of TOR phosphorylation under normal conditions, inhibition of TOR by rapamycin or leucine deprivation leads to dephosphorylation of ATG13, ULK1 and ULK2, which then leads to autophagy.ATG101 also interacts with ULK1 and is essential for autophagy.
    Synonyms: Autophagy-related protein 101, ATG13-interacting protein
    NCBI Accession
    NP_001092143
    Pathways
    Autophagy
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