This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This mouse Tfap2a antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 134-166 amino acids from the Central region of mouse Tfap2a.
TFAP2A
Reactivity: Human
WB
Host: Rabbit
Polyclonal
unconjugated
Application Notes
WB: 1:1000
Restrictions
For Research Use only
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Expiry Date
6 months
Yahata, Takedatsu, Dunwoodie, Bragança, Swingler, Withington, Hur, Coser, Isselbacher, Bhattacharya, Shioda: "Cloning of mouse Cited4, a member of the CITED family p300/CBP-binding transcriptional coactivators: induced expression in mammary epithelial cells." in: Genomics, Vol. 80, Issue 6, pp. 601-13, (2002) (PubMed).
Meier, Koedood, Philipp, Fontana, Mitchell: "Alternative mRNAs encode multiple isoforms of transcription factor AP-2 during murine embryogenesis." in: Developmental biology, Vol. 169, Issue 1, pp. 1-14, (1995) (PubMed).
Moser, Pscherer, Bauer, Imhof, Seegers, Kerscher, Buettner: "The complete murine cDNA sequence of the transcription factor AP-2." in: Nucleic acids research, Vol. 21, Issue 20, pp. 4844, (1993) (PubMed).
Mitchell, Timmons, Hébert, Rigby, Tjian: "Transcription factor AP-2 is expressed in neural crest cell lineages during mouse embryogenesis." in: Genes & development, Vol. 5, Issue 1, pp. 105-19, (1991) (PubMed).
Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.