FFAR1 antibody (AA 210-222)

Catalog No. ABIN2450556

Product Details anti-FFAR1 Antibody

Target: FFAR1 (Free Fatty Acid Receptor 1 (FFAR1))

Binding Specificity: AA 210-222

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FFAR1 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Specificity: GPR40 is a seven transmembrane G Protein-coupled receptor with signalling mediated by medium- and long-chain fatty acids. Found predominantly in the beta-cells of pancreatic islets, it has been implicated in the regulation of insulin secretion. Overexpression of GPR40 in mouse beta cells leads to glucose intolerance suggesting a link between GPR40 expression and diabetes. The receptor has also been identified as a possible mediator of oleate- and linoleate- stimulated proliferation of the human breast cancer cell line, MCF-7. GPR40 has a calculated mass of 31.4 kDa bases on its amino acid sequence.

Purification: Affinity purified

Immunogen: human GPR40 amino acids 210-222

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: TBS,  pH 7.4, containing 50 % glycerol, 0.5 mg/mL BSA, and 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C, stable for 1 year. Avoid freeze-thaw cycles.

Target Details for FFAR1

Target: FFAR1 (Free Fatty Acid Receptor 1 (FFAR1))

Alternative Name: FFAR1 / GPR40 (FFAR1 Products)

Synonyms: FFAR1 antibody, GPR40 antibody, FFA1R antibody, GPCR40 antibody, Gpr40 antibody, free fatty acid receptor 1 antibody, FFAR1 antibody, Ffar1 antibody

Background: Name/Gene ID: FFAR1
Subfamily: Carboxylic Acid
Family: GPCR

Synonyms: FFAR1, FFAR, FFA1R, G protein-coupled receptor 40, GPCR40, GPR40, Free fatty acid receptor, Free fatty acid receptor 1, G-protein coupled receptor 40

Gene ID: 2864

Pathways: Positive Regulation of Peptide Hormone Secretion, Hormone Transport, Peptide Hormone Metabolism, Carbohydrate Homeostasis