NCOA3 antibody

Catalog No. ABIN2457957

Product Details anti-NCOA3 Antibody

Target: NCOA3 (Nuclear Receptor Coactivator 3 (NCOA3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NCOA3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human NCOA3.

Application Details

Application Notes: NCOA3 antibody can be used for detection of NCOA3 by ELISA at 1:312500. NCOA3 antibody can be used for detection of NCOA3 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store NCOA3 antibody at -20 °C.

Target Details for NCOA3

Target: NCOA3 (Nuclear Receptor Coactivator 3 (NCOA3))

Alternative Name: NCOA3 (NCOA3 Products)

Synonyms: NCOA3 antibody, ACTR antibody, AIB-1 antibody, AIB1 antibody, CAGH16 antibody, CTG26 antibody, KAT13B antibody, RAC3 antibody, SRC-3 antibody, SRC3 antibody, TNRC14 antibody, TNRC16 antibody, TRAM-1 antibody, bHLHe42 antibody, pCIP antibody, 2010305B15Rik antibody, AW321064 antibody, Actr antibody, Aib1 antibody, Rac3 antibody, Src3 antibody, Tram-1 antibody, Tram1 antibody, p/Cip antibody, pCip antibody, actr antibody, aib-1 antibody, aib1 antibody, cagh16 antibody, ctg26 antibody, kat13b antibody, pcip antibody, rac3 antibody, src-3 antibody, src3 antibody, tnrc14 antibody, tnrc16 antibody, tram-1 antibody, xSRC-3 antibody, nuclear receptor coactivator 3 antibody, nuclear receptor coactivator 3 S homeolog antibody, NCOA3 antibody, Ncoa3 antibody, ncoa3.S antibody

Background: NCOA3 is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Two transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein.The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Two transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein.

Molecular Weight: 155 kDa

Gene ID: 8202

NCBI Accession: NP_006525

UniProt: Q0VF45

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Lipid Metabolism by PPARalpha