DREAM antibody

Catalog No. ABIN2460323

Product Details anti-DREAM Antibody

Target: DREAM (KCNIP3) (Kv Channel Interacting Protein 3, Calsenilin (KCNIP3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DREAM antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Purification: Antibody is purified by peptide affinity chromatography method.

Immunogen: Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human CSEN.

Application Details

Application Notes: CSEN antibody can be used for detection of CSEN by ELISA at 1:12500. CSEN antibody can be used for detection of CSEN by western blot at 2.0 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Add 50 ?L of distilled water. Final antibody concentration is 1 mg/mL.

Concentration: 1 mg/mL

Buffer: Antibody is lyophilized in PBS buffer with 2 % sucrose.

Handling Advice: As with any antibody avoid repeat freeze-thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: For short periods of storage (days) store at 4 °C. For longer periods of storage, store CSEN antibody at -20 °C.

Target Details for DREAM

Target: DREAM (KCNIP3) (Kv Channel Interacting Protein 3, Calsenilin (KCNIP3))

Alternative Name: CSEN (KCNIP3 Products)

Synonyms: CSEN antibody, DREAM antibody, KCHIP3 antibody, 4933407H12Rik antibody, AI413860 antibody, Csen antibody, KChIP3 antibody, R74849 antibody, Dream antibody, rKChIP3 antibody, csen antibody, im:7145308 antibody, kcnip3 antibody, zgc:73306 antibody, KCNIP3 antibody, potassium voltage-gated channel interacting protein 3 antibody, Kv channel-interacting protein 4 antibody, calsenilin antibody, Kv channel interacting protein 3, calsenilin antibody, Kv channel interacting protein 3b, calsenilin antibody, KCNIP3 antibody, LOC5568664 antibody, CpipJ_CPIJ002549 antibody, Tsp_05009 antibody, Kcnip3 antibody, kcnip3b antibody, kcnip3 antibody

Background: CSEN is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The protein encoded by this gene is also shown to function as a calcium-regulated transcriptional repressor, and to interact with presenilins. Mutations in the presenilin genes have been implicated in Alzheimer's disease.

Molecular Weight: 29 kDa

Gene ID: 30818

NCBI Accession: NP_038462

UniProt: Q9Y2W7