NCOR2 antibody
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- Target See all NCOR2 Antibodies
- NCOR2 (Nuclear Receptor Co-Repressor 2 (NCOR2))
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This NCOR2 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA
- Purification
- Antibody is purified by protein A chromatography method.
- Immunogen
- Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human NCOR2.
- Top Product
- Discover our top product NCOR2 Primary Antibody
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- Application Notes
- NCOR2 antibody can be used for detection of NCOR2 by ELISA at 1:62500. NCOR2 antibody can be used for detection of NCOR2 by western blot at 2.5 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 100 ?L of distilled water. Final antibody concentration is 1 mg/mL.
- Concentration
- 1 mg/mL
- Buffer
- Antibody is lyophilized in PBS buffer with 2 % sucrose.
- Handling Advice
- As with any antibody avoid repeat freeze-thaw cycles.
- Storage
- 4 °C/-20 °C
- Storage Comment
- For short periods of storage (days) store at 4 °C. For longer periods of storage, store NCOR2 antibody at -20 °C.
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- Target
- NCOR2 (Nuclear Receptor Co-Repressor 2 (NCOR2))
- Alternative Name
- NCOR2 (NCOR2 Products)
- Synonyms
- CTG26 antibody, N-CoR2 antibody, SMAP270 antibody, SMRT antibody, SMRTE antibody, SMRTE-tau antibody, TNRC14 antibody, TRAC antibody, TRAC-1 antibody, TRAC1 antibody, N-CoR antibody, SMRTe antibody, NCOR2 antibody, gb:be017685 antibody, si:bz71m17.2 antibody, smrt antibody, ctg26 antibody, smrte antibody, trac1 antibody, tnrc14 antibody, trac-1 antibody, smrte-tau antibody, nuclear receptor corepressor 2 antibody, nuclear receptor co-repressor 2 antibody, NCOR2 antibody, Ncor2 antibody, ncor2 antibody
- Background
- NCOR2 forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interaction with TFIIB. NCOR2 mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription.Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.
- Molecular Weight
- 275 kDa
- Gene ID
- 9612
- NCBI Accession
- NP_006303
- UniProt
- Q9Y618
- Pathways
- Notch Signaling, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha
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