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LCK antibody (truncated)
LCK
Reactivity: Human
WB, ELISA
Host: Mouse
Monoclonal
8E5F9-4B2C7
unconjugated
Product Details anti-LCK Antibody
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Target
See all LCK Antibodies
LCK
(Lymphocyte-Specific Protein tyrosine Kinase (LCK))
Binding Specificity
All epitopes for LCK antibodies
truncated
Reactivity
All reactivities for LCK antibodies
Human
Host
All hosts for LCK antibodies
Mouse
Clonality
All clonalities for LCK antibodies
Monoclonal
Conjugate
All conjugates for LCK antibodies
This LCK antibody is un-conjugated
Application
All applications for LCK antibodies
Western Blotting (WB), ELISA
Immunogen
Ni-NTA purified truncated recombinant Lck expressed in E. Coli strain BL21 (DE3).
Clone
8E5F9-4B2C7
Isotype
IgG2a
Top Product
Discover our top product LCK Primary Antibody
Alternatives
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Application Details
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Application Notes
Western Blot:1:500 - 1:2,000 ELISA:Propose dilution 1:10,000. Determining optimal working dilutions by titration test.
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
Ascitic fluid containing 0.03 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Storage
-20 °C
Storage Comment
Lck monoclonal antibody can be stored at -20 °C, stable for one year.
Target Details for LCK
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Target
LCK
(Lymphocyte-Specific Protein tyrosine Kinase (LCK))
Alternative Name
Lck (LCK Products )
Synonyms
zgc:136695 antibody, LCK antibody, Hck-3 antibody, Lsk antibody, Lskt antibody, p56 antibody, p56Lck antibody, LSK antibody, YT16 antibody, p56lck antibody, pp58lck antibody, P56LCK antibody, tkl antibody, Lck1 antibody, Lcktkr antibody, LCK proto-oncogene, Src family tyrosine kinase antibody, lymphocyte protein tyrosine kinase antibody, lck antibody, LCK antibody, Lck antibody
Background
Lck(lymphocyte-specific protein tyrosine kinase), with 509-amino acid protein (about 56 kDa), belongs to the Src non-receptor tyrosine kinases family. By virtue of common structural motifs, the Src family is composed of nine members in vertebrates, including Src, Yes, Fgr, Frk, Fyn, Lyn, Hck, Lck and Blk. Lck is expressed predominantly in T cells and is localized to the inner surface of the plasma membrane. Lck is activated after T cell stimulation and is required for T-cell proliferation and IL-2 production. Aberrant expression or activation of Lck kinase has been reported in both lymphoid and nonlymphoid malignancies. In addition, inhibition of Lck has been a target to prevent lymphocyte activation and acute rejection.
Gene ID
3932
UniProt
P06239
Pathways
TCR Signaling , Fc-epsilon Receptor Signaling Pathway , EGFR Signaling Pathway , Neurotrophin Signaling Pathway , Transition Metal Ion Homeostasis , Positive Regulation of Endopeptidase Activity , CXCR4-mediated Signaling Events , Thromboxane A2 Receptor Signaling
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