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MCL-1 antibody
MCL1
Reactivity: Human
WB, ELISA, IHC
Host: Mouse
Monoclonal
8C6D4B1
unconjugated
Product Details anti-MCL-1 Antibody
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Target
See all MCL-1 (MCL1) Antibodies
MCL-1 (MCL1)
(Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1))
Reactivity
All reactivities for MCL-1 antibodies
Human
Host
All hosts for MCL-1 antibodies
Mouse
Clonality
All clonalities for MCL-1 antibodies
Monoclonal
Conjugate
All conjugates for MCL-1 antibodies
This MCL-1 antibody is un-conjugated
Application
All applications for MCL-1 antibodies
Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
Purification
Antibody is purified by protein G affinity chromatography.
Immunogen
Ni-NTA purified recombinant protein MCL-1expressed in E. Coli strain M15.
Clone
8C6D4B1
Isotype
IgG1
Top Product
Discover our top product MCL1 Primary Antibody
Alternatives
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Application Details
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Application Notes
Western Blot:Dilution 1:200 - 1:1,000 IHC(P):Dilution 1:200 - 1:1,000 IHC(F):Dilution 1:200 - 1:1,000 ELISA:Propose dilution 1:10,000. Determining optimal working dilutions by titration test.
Restrictions
For Research Use only
Handling
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Handling Advice
As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Storage
-20 °C
Storage Comment
MCL-1 monoclonal antibody can be stored at -20 °C, stable for one year.
Target Details for MCL-1
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Target
MCL-1 (MCL1)
(Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1))
Alternative Name
MCL1 (MCL1 Products )
Synonyms
BCL2L3 antibody, EAT antibody, MCL1-ES antibody, MCL1L antibody, MCL1S antibody, Mcl-1 antibody, TM antibody, bcl2-L-3 antibody, mcl1/EAT antibody, AW556805 antibody, mcl-1 antibody, fb72f02 antibody, wu:fb70a08 antibody, wu:fb72f02 antibody, zfMLP1 antibody, zfMcl-1a antibody, zgc:109835 antibody, zgc:109763 antibody, E3 antibody, E3-2 antibody, RNE3 antibody, RNU107 antibody, SNORA63A antibody, elF-4AII antibody, MCL1, BCL2 family apoptosis regulator antibody, myeloid cell leukemia sequence 1 antibody, MCL1, BCL2 family apoptosis regulator a antibody, MCL1, BCL2 family apoptosis regulator b antibody, small nucleolar RNA, H/ACA box 63 antibody, MCL1 antibody, Mcl1 antibody, mcl1a antibody, mcl1b antibody, SNORA63 antibody
Background
Mcl-1 (Myeloid cell leukemia-1) is Bcl-2-related and was identified as an early-induction gene that increased in expression during the differentiation of human myeloblastic leukemia cell ML-1, or exposure to different DNA damaging agents. The level of Mcl-1 is decreased in peripheral B lymphocytes undergoing apoptosis following treatment with apoptotic stimuli such as TGF-alpha 1 and forskolin. Expression of Mcl-1 is able to delay apoptosis induced by over-expression of c-myc in CHO 5AHSmyc cells. In hematopoietic FDC-P1 cells, Mcl-1 interacts with another Bcl-2-related protein, Bax, and prolongs cell viability after treatment with different apoptotic reagents.This monoclonal antibody detected a 37kd MCL1 in BCBL-1 cell lysate.
Gene ID
4170
NCBI Accession
NP_001184249
UniProt
Q07820
Pathways
MAPK Signaling
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