TYMS antibody

Catalog No. ABIN2466868

Product Details anti-TYMS Antibody

Target: TYMS (Thymidylate Synthetase (TYMS))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TYMS antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Purification: Protein G-purified

Immunogen: Recombinant human thymidylate synthase produced in E. coli.

Clone: 2D8-D11

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS

Handling Advice: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Storage: 4 °C

Storage Comment: Thymidylate Synthase monoclonal Antibodies can be stored at 4 °C, stable for one year.

Target Details for TYMS

Target: TYMS (Thymidylate Synthetase (TYMS))

Alternative Name: Thymidylate Synthase (TYMS Products)

Synonyms: FN1 antibody, ECK2823 antibody, JW2795 antibody, ts antibody, Ts antibody, HST422 antibody, TMS antibody, TS antibody, thymidylate synthetase antibody, contains intron in T4 phage antibody, ThyE antibody, thymidylate synthase antibody, thymidylate synthetase L homeolog antibody, TYMS antibody, thyA antibody, td antibody, thyE antibody, DDA3937_RS04960 antibody, tyms.L antibody, XBJ1_RS15770 antibody, EAMY_RS20680 antibody, Tyms antibody

Target Type: Viral Protein

Background: Thymidylate synthase (TS) is anintracellular enzyme critical for de novosynthesis of DNA. In cancer,expression of TS is often elevated and becomes further elevated as a result of treatment with the most commonly used chemotherapeutic, 5-fluorouracil (5-FU). Resistance or lack of response to 5-FU is attributed to the elevation of TS activity. Overexpression of TS has been demonstrated in many types of tumors including breast, colon, gastric and melanoma and is usually predictive of shortened survival time.

Gene ID: 5888

NCBI Accession: NP_001157741

UniProt: Q06609

Pathways: Mitotic G1-G1/S Phases