LDLR antibody (AA 29-205)

Catalog No. ABIN2467854

Product Details anti-LDLR Antibody

Target: LDLR (Low Density Lipoprotein Receptor (LDLR))

Binding Specificity: AA 29-205

Reactivity: Human, Mouse, Rat

Host: Chicken

Clonality: Polyclonal

Conjugate: This LDLR antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Antigen affinity-purified

Application Details

Application Notes: LDL-R antibody can be used for the detection of LDL-R by Western blot, may also work for IHC and ICC.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate-Buffered Saline. No preservatives added.

Preservative: Without preservative

Handling Advice: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Storage: 4 °C/-20 °C

Storage Comment: LDLR antibody can be stored at 4 °C for short term (weeks). Long term storage should be at -20 °C.

Target Details for LDLR

Target: LDLR (Low Density Lipoprotein Receptor (LDLR))

Alternative Name: LDLR (LDLR Products)

Synonyms: FH antibody, FHC antibody, LDLCQ2 antibody, Hlb301 antibody, LDLRA antibody, LDLA antibody, LDL receptor-2 antibody, fhc antibody, ldlcq2 antibody, ldlr antibody, ldlr2-a antibody, LDL receptor 1 antibody, ldlr-a antibody, ldlr-b antibody, low density lipoprotein receptor antibody, low density lipoprotein receptor a antibody, low density lipoprotein receptor S homeolog antibody, low density lipoprotein receptor L homeolog antibody, LDLR antibody, Ldlr antibody, ldlra antibody, ldlr.S antibody, ldlr.L antibody

Background: Low density lipoprotein receptor. The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia.

Molecular Weight: 95.4 kDa (calculated)

Gene ID: 3949

NCBI Accession: NP_000518

UniProt: P01130

Pathways: Hepatitis C, Lipid Metabolism