KIF7 antibody (C-Term)

Catalog No. ABIN2490336

Product Details anti-KIF7 Antibody

Target: KIF7 (Kinesin Family Member 7 (KIF7))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat, Pig, Cow, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KIF7 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: RDLVHAPLPL TWKRSSLCGE EQGSPEELRQ REAAEPLVGR VLPVGEAGLP

Predicted Reactivity: Cow: 92%, Dog: 79%, Human: 100%, Mouse: 77%, Pig: 100%, Rat: 77%

Characteristics: This is a rabbit polyclonal antibody against KIF7. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of human KIF7

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for KIF7

Target: KIF7 (Kinesin Family Member 7 (KIF7))

Alternative Name: KIF7 (KIF7 Products)

Synonyms: KIF7 antibody, DDBDRAFT_0204609 antibody, DDBDRAFT_0206583 antibody, DDB_0204609 antibody, DDB_0206583 antibody, ACLS antibody, HLS2 antibody, JBTS12 antibody, UNQ340 antibody, cos2 antibody, costal2 antibody, kinesin family member 7 antibody, KIF7 antibody, kif7 antibody, Kif7 antibody

Background: This gene encodes a cilia-associated protein belonging to the kinesin family. This protein plays a role in the sonic hedgehog (SHH) signaling pathway through the regulation of GLI transcription factors. It functions as a negative regulator of the SHH pathway by preventing inappropriate activation of GLI2 in the absence of ligand, and as a positive regulator by preventing the processing of GLI3 into its repressor form. Mutations in this gene have been associated with various ciliopathies.
Alias Symbols: ACLS, AGBK, HLS2, JBTS12, UNQ340
Protein Size: 829

Molecular Weight: 91 kDa

Gene ID: 374654

NCBI Accession: NM_198525, NP_940927

UniProt: Q2M1P5

Pathways: Hedgehog Signaling