This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class, in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Protein Interaction Partner: USP18, CUL1, CDKN1A, SAMHD1, SUGT1, UBC, AR, RND3, CKS1B, MYC, SMAD7, CDKN1B, SKP1, CDK3, CDK2, LATS2, FZR1, CEP192, SF3B3, KMT2A, E2F1, KPNA6, SIRT3, SIRT4, RBX1, CDC14B, NEDD8, SIRT6, KPNA1, HSP90AA1, EP300, CEBPA, CDH1, BRCA1, BARD1, BTRC, SNRPB2, CDC3 Protein Size: 210