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TCF3 antibody (N-Term)
TCF3
Reactivity: Human, Mouse, Rat, Dog, Horse
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-TCF3 Antibody
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Target
See all TCF3 Antibodies
TCF3
(Transcription Factor 3 (E2A Immunoglobulin Enhancer Binding Factors E12/E47) (TCF3))
Binding Specificity
All epitopes for TCF3 antibodies
N-Term
Reactivity
All reactivities for TCF3 antibodies
Human, Mouse, Rat, Dog, Horse
Host
All hosts for TCF3 antibodies
Rabbit
Clonality
All clonalities for TCF3 antibodies
Polyclonal
Conjugate
All conjugates for TCF3 antibodies
This TCF3 antibody is un-conjugated
Application
All applications for TCF3 antibodies
Western Blotting (WB)
Sequence
EDRPSSGSWG SGDQSSSSFD PSRTFSEGTH FTESHSSLSS STFLGPGLGG
Predicted Reactivity
Dog: 86%, Horse: 85%, Human: 100%, Mouse: 86%, Rat: 79%
Characteristics
This is a rabbit polyclonal antibody against TCF3. It was validated on Western Blot.
Purification
Affinity Purified
Immunogen
The immunogen is a synthetic peptide directed towards the N-terminal region of Human TCF3
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeat freeze-thaw cycles.
Storage
-20 °C
Storage Comment
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Target Details for TCF3
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Target
TCF3
(Transcription Factor 3 (E2A Immunoglobulin Enhancer Binding Factors E12/E47) (TCF3))
Alternative Name
TCF3 (TCF3 Products )
Synonyms
E2A antibody, E47 antibody, ITF1 antibody, TCF-3 antibody, VDIR antibody, bHLHb21 antibody, tcf3a antibody, zgc:113045 antibody, A1 antibody, AA408400 antibody, ALF2 antibody, AW209082 antibody, E12 antibody, E12/E47 antibody, ME2 antibody, Pan1 antibody, Pan2 antibody, Tcfe2a antibody, bhlhb21 antibody, e2a antibody, itf1 antibody, tcfe2a antibody, vdir antibody, xtcf-3 antibody, xtcf3 antibody, G12 antibody, TCF7L1 antibody, XE3 antibody, transcription factor 3 antibody, transcription factor 3b antibody, transcription factor 3 L homeolog antibody, transcription factor E2a antibody, TCF3 antibody, tcf3b antibody, Tcf3 antibody, tcf3.L antibody, tcfe2a antibody
Background
TCF3 is a transcriptional regulator. It is involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. TCF3 binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. It binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region. Alias Symbols: E2A, E47, ITF1, TCF-3, VDIR, bHLHb21 Protein Interaction Partner: ID3, FAM115A, TLE1, RNF14, UBC, SCX, MAPKAPK2, MAPKAPK3, TCF21, Ube2i, ID2, FUS, CTNNB1, RPL37, MAX, USF1, TCF12, TCF3, MYOD1, Rufy1, Tfap4, Rpa1, Tbx6, Ncl, Twist2, SUPT3H, TRRAP, KAT2A, TADA2A, FOXH1, ELAVL1, TCF24, SETSIP, FLG2, BHLHA15, MYL6B, TIMM50, Protein Size: 654
Molecular Weight
71 kDa
Gene ID
6929
NCBI Accession
NM_003200 , NP_003191
UniProt
P15923
Pathways
WNT Signaling , Stem Cell Maintenance , Regulation of Muscle Cell Differentiation , Production of Molecular Mediator of Immune Response
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