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ATF2 antibody (pSer472)
ATF2
Reactivity: Human, Mouse, Rat
IHC
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-ATF2 Antibody
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Target
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ATF2
(Activating Transcription Factor 2 (ATF2))
Binding Specificity
All epitopes for ATF2 antibodies
pSer472
Reactivity
All reactivities for ATF2 antibodies
Human, Mouse, Rat
Host
All hosts for ATF2 antibodies
Rabbit
Clonality
All clonalities for ATF2 antibodies
Polyclonal
Conjugate
All conjugates for ATF2 antibodies
This ATF2 antibody is un-conjugated
Application
All applications for ATF2 antibodies
Immunohistochemistry (IHC)
Specificity
The antibody detects endogenous levels of ATF-2 only when phosphorylated at serine 472.
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Immunogen
ATF-2 (phospho Ser472) antibody was raised against a peptide sequence around phosphorylation site of Serine 472 (E-A-V (p)-A-T) derived from Human ATF-2.
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store antibody at -20°C for up to one year.
Target Details for ATF2
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Target
ATF2
(Activating Transcription Factor 2 (ATF2))
Alternative Name
ATF-2 (ATF2 Products )
Synonyms
CRE-BP1 antibody, CREB2 antibody, HB16 antibody, TREB7 antibody, CG12850 antibody, CG3749 antibody, dATF-2 antibody, DmelCG30420 antibody, CG30420 antibody, CHN1 antibody, Atf-2 antibody, CRE-BP antibody, Creb2 antibody, D130078H02Rik antibody, D18875 antibody, Tg(Gzma-Klra1)7Wum antibody, mXBP antibody, atf2-A antibody, atf2l antibody, activating transcription factor 2 antibody, Activating transcription factor-2 antibody, activating transcription factor 2 S homeolog antibody, ATF2 antibody, Atf-2 antibody, Atf2 antibody, atf2.S antibody, atf2 antibody
Background
Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2-c-Jun complex.
Molecular Weight
54 kDa
Gene ID
1386
NCBI Accession
NP_001243019
UniProt
P15336
Pathways
MAPK Signaling , RTK Signaling , Thyroid Hormone Synthesis , Activation of Innate immune Response , Chromatin Binding , Myometrial Relaxation and Contraction , Synaptic Membrane , Tube Formation , Toll-Like Receptors Cascades
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