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CDK1 antibody (pThr14)
CDK1
Reactivity: Human, Mouse, Rat
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-CDK1 Antibody
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Target
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CDK1
(Cyclin-Dependent Kinase 1 (CDK1))
Binding Specificity
All epitopes for CDK1 antibodies
pThr14
Reactivity
All reactivities for CDK1 antibodies
Human, Mouse, Rat
Host
All hosts for CDK1 antibodies
Rabbit
Clonality
All clonalities for CDK1 antibodies
Polyclonal
Conjugate
All conjugates for CDK1 antibodies
This CDK1 antibody is un-conjugated
Application
All applications for CDK1 antibodies
Western Blotting (WB)
Specificity
The antibody detects endogenous level of CDK1/CDC2 only when phosphorylated at threonine 14.
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Immunogen
CDK1/CDC2 (phospho Thr14) antibody was raised against a peptide sequence around phospho rylation site of threonine14 (E-G-T (p)-Y-G) derived from Human CDK1/CDC2 .
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
Western Blot: 1:500~1:1000
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store antibody at -20°C for up to one year.
Target Details for CDK1
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Target
CDK1
(Cyclin-Dependent Kinase 1 (CDK1))
Alternative Name
CDK1/CDC2 (CDK1 Products )
Synonyms
CDC2 antibody, CDC28A antibody, P34CDC2 antibody, Cdc2 antibody, Cdc2a antibody, p34 antibody, cdc2 antibody, wu:fc30e01 antibody, zgc:92032 antibody, PSTAIR antibody, cdc-2 antibody, cdc2-a antibody, cdc28a antibody, cdc2x1.1 antibody, p34cdc2 antibody, xcdc2 antibody, 5363 antibody, CDCDm antibody, CDK1 antibody, CDK1/CDC2 antibody, CG5363 antibody, Cdk-1 antibody, Cdk1 antibody, Dcdc2 antibody, Dm cdc2 antibody, DmCdc2 antibody, DmCdk1 antibody, Dmcdc2 antibody, Dmel\\CG5363 antibody, cdc antibody, cdc2Dm antibody, cdk1 antibody, dCdk1 antibody, group 4 antibody, l(2)31Eh antibody, CDC2A antibody, CDC2AAT antibody, CDK2 antibody, CDKA1 antibody, CDKA;1 antibody, CYCLIN-DEPENDENT KINASE A;1 antibody, cell division control 2 antibody, cdc2-b antibody, cdc2a antibody, cdc2x1.2 antibody, POL3 antibody, pold antibody, cyclin dependent kinase 1 antibody, cyclin dependent kinase like 1 antibody, Cell division control protein 2 1 antibody, cyclin-dependent kinase 1 antibody, cyclin-dependent kinase 1 S homeolog antibody, Cyclin-dependent kinase 1 antibody, cell division control 2 antibody, cell division control protein2 homolog antibody, cyclin-dependent kinase 1 L homeolog antibody, polymerase (DNA directed), delta 1, catalytic subunit L homeolog antibody, cyclin-dependent protein kinase Cdk1/Cdc2 antibody, CDK1 antibody, CDKL1 antibody, POPTR_0004s14080g antibody, Cdk1 antibody, cdk1 antibody, cdk1.S antibody, CDC2 antibody, cdc2 antibody, cdk-1 antibody, cdk1.L antibody, pold1.L antibody
Background
Serine/threonine-protein kinase involved in the control of the cell cycle, essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression, controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus.
Molecular Weight
34 kDa
Gene ID
1017
NCBI Accession
NP_001277159
UniProt
P24941
Pathways
Cell Division Cycle , Fc-epsilon Receptor Signaling Pathway , Neurotrophin Signaling Pathway , Activation of Innate immune Response , Mitotic G1-G1/S Phases , DNA Replication , M Phase , Toll-Like Receptors Cascades , Synthesis of DNA
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