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IGF1R antibody (pTyr1346)
IGF1R
Reactivity: Human, Mouse, Rat
IHC
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-IGF1R Antibody
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Target
See all IGF1R Antibodies
IGF1R
(Insulin-Like Growth Factor 1 Receptor (IGF1R))
Binding Specificity
All epitopes for IGF1R antibodies
pTyr1346
Reactivity
All reactivities for IGF1R antibodies
Human, Mouse, Rat
Host
All hosts for IGF1R antibodies
Rabbit
Clonality
All clonalities for IGF1R antibodies
Polyclonal
Conjugate
All conjugates for IGF1R antibodies
This IGF1R antibody is un-conjugated
Application
All applications for IGF1R antibodies
Immunohistochemistry (IHC)
Specificity
The antibody detects endogenous levels of IGF1R only when phosphorylated at tyrosine 1346.
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Immunogen
IGF1R (phospho Tyr1346) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 1346 (Q-P-Y (p)-A-H) derived from Human IGF1R .
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store antibody at -20°C for up to one year.
Target Details for IGF1R
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Target
IGF1R
(Insulin-Like Growth Factor 1 Receptor (IGF1R))
Alternative Name
IGF1R (IGF1R Products )
Synonyms
CMT2N antibody, CD221 antibody, IGFIR antibody, IGFR antibody, JTK13 antibody, IGFIRC antibody, IGFR1 antibody, IGF-1R antibody, IGF1R antibody, DKFZp469I0618 antibody, igf-1r antibody, xIGF-1R antibody, xIGFR antibody, xigf1r antibody, A330103N21Rik antibody, D930020L01 antibody, hyft antibody, igf-ir antibody, IGF-IR antibody, IGF-IRb antibody, wu:fb03h06 antibody, IGF-IRa antibody, sb:eu1090 antibody, wu:fi20b10 antibody, alanyl-tRNA synthetase antibody, insulin like growth factor 1 receptor antibody, insulin-like growth factor 1 receptor antibody, insulin-like growth factor 1 antibody, insulin-like growth factor I receptor antibody, insulin like growth factor 1 receptor S homeolog antibody, insulin-like growth factor 1b receptor antibody, insulin-like growth factor 1a receptor antibody, AARS antibody, IGF1R antibody, Igf1r antibody, igf1r antibody, Igf1 antibody, LOC780503 antibody, LOC100136427 antibody, igf1r.S antibody, igf1rb antibody, igf1ra antibody
Background
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.
Molecular Weight
154 kDa
Gene ID
3480
NCBI Accession
NP_000866
UniProt
P08069
Pathways
RTK Signaling , Regulation of Hormone Metabolic Process , Regulation of Hormone Biosynthetic Process , Autophagy
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