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PAK2 antibody (pSer197)
PAK2
Reactivity: Human, Mouse, Rat
IHC
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-PAK2 Antibody
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Target
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PAK2
(P21-Activated Kinase 2 (PAK2))
Binding Specificity
All epitopes for PAK2 antibodies
pSer197
Reactivity
All reactivities for PAK2 antibodies
Human, Mouse, Rat
Host
All hosts for PAK2 antibodies
Rabbit
Clonality
All clonalities for PAK2 antibodies
Polyclonal
Conjugate
All conjugates for PAK2 antibodies
This PAK2 antibody is un-conjugated
Application
All applications for PAK2 antibodies
Immunohistochemistry (IHC)
Specificity
The antibody detects endogenous levels of PAK2 only when phosphorylated at serine 197.
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Immunogen
PAK2 (phospho Ser197) antibody was raised against a peptide sequence around phosphorylation site of Serine 197 (T-R-S (p)-V-I) derived from Human PAK2.
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store antibody at -20°C for up to one year.
Target Details for PAK2
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Target
PAK2
(P21-Activated Kinase 2 (PAK2))
Alternative Name
PAK2 (PAK2 Products )
Synonyms
PAK65 antibody, PAKgamma antibody, gamma-PAK antibody, 5330420P17Rik antibody, A130002K10Rik antibody, AI836325 antibody, D16Ertd269e antibody, PAK-2 antibody, mKIAA4182 antibody, pak2 antibody, cb422 antibody, kinase antibody, zgc:91798 antibody, wu:fb71h01 antibody, si:dz198m22.1 antibody, pak65 antibody, pakgamma antibody, PAKI antibody, Pak3 antibody, CH73-159L23.1 antibody, wu:fc52b03 antibody, zgc:113857 antibody, p21 (RAC1) activated kinase 2 antibody, p21 protein (Cdc42/Rac)-activated kinase 2 antibody, p21 protein (Cdc42/Rac)-activated kinase 2a antibody, p21 protein (Cdc42/Rac)-activated kinase 2 S homeolog antibody, p21 protein (Cdc42/Rac)-activated kinase 2b antibody, PAK2 antibody, Pak2 antibody, pak2a antibody, pak2.S antibody, pak2b antibody
Background
The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2.
Molecular Weight
58 kDa
Gene ID
5062
NCBI Accession
NP_002568
UniProt
Q13177
Pathways
MAPK Signaling , RTK Signaling , TCR Signaling , Fc-epsilon Receptor Signaling Pathway , Regulation of Lipid Metabolism by PPARalpha
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