The antibody detects endogenous levels of TGF beta Receptor II only when phosphorylated at serine 225/250.
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Immunogen
TGF beta Receptor II (phospho Ser225/250) antibody was raised against a peptide sequence around phosphorylation site of Serine 225/250 (D-R-S (p)-D-I) derived from Human TGF beta Receptor II.
Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis.