Glycogen Synthase antibody

Catalog No. ABIN265444

Product Details anti-Glycogen Synthase Antibody

Target: Glycogen Synthase (GYS)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Glycogen Synthase antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody detects endogenous levels of Glycogen Synthase protein. (region surrounding Pro539)

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Purity: > 95 % pure by SDS-PAGE

Application Details

Application Notes: ELISA: 1: 5000approx. 1: 20000. WB: 1: 500approx. 1: 1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.2., 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: DO NOT FREEZE!

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for Glycogen Synthase

Target: Glycogen Synthase (GYS)

Alternative Name: Glycogen Synthase (GYS Products)

Synonyms: CG6940 antibody, Dmel\\CG6904 antibody, anon-WO0118547.108 antibody, glycogen synthase antibody, Glycogen synthase antibody, starch synthase antibody, glgA antibody, GlyS antibody, glgA-2 antibody, glgA-1 antibody, EAMY_RS33325 antibody, Hipma_0956 antibody, Tresu_1353 antibody, Spico_0935 antibody, Trebr_1511 antibody, Mahau_1987 antibody

Background: Glycogen (starch) synthase belongs to the mammalian/fungal glycogen synthase family of proteins. Two forms of this protein exist, a liver form and a muscle form, both of which have the same function in the glycogen biosynthesis pathway. Glycogen synthase transfers the glycosyl residue from UDP-glucose to the nonreducing end of α-1,4-glucan. The 81 kDa liver glycogen synthase protein is truncated by 34 amino acids compared to the muscle form. However, these enzymes differ significantly in their amino- and carboxyl-terminal regions. Muscle glycogen synthase serves to fuel muscular activity only and is regulated by muscle contraction and by catecholamines. Liver glycogen synthase mediates blood glucose homeostasis in response to nutritional cues. Defects in the gene encoding liver glycogen synthase results in glycogen storage disease type 0 (GSD0), a rare form of fasting ketotic hypoglycemia.Synonyms: GYS, GYS1, muscle Glycogen Synthase

Molecular Weight: approx. 84 kDa

Gene ID: 2997

NCBI Accession: NP_001155059

UniProt: P13807