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PARP1 antibody (AA 215-525)
PARP1
Reactivity: Human, Mouse
WB, IHC, IP, ICC
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-PARP1 Antibody
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Target
See all PARP1 Antibodies
PARP1
(Poly (ADP-Ribose) Polymerase 1 (PARP1))
Binding Specificity
All epitopes for PARP1 antibodies
AA 215-525
Reactivity
All reactivities for PARP1 antibodies
Human, Mouse
Host
All hosts for PARP1 antibodies
Rabbit
Clonality
All clonalities for PARP1 antibodies
Polyclonal
Conjugate
All conjugates for PARP1 antibodies
This PARP1 antibody is un-conjugated
Application
All applications for PARP1 antibodies
Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC)
Specificity
Recognizes mouse PARP-1.
Cross-Reactivity
Human, Mouse (Murine)
Cross-Reactivity (Details)
Cross-reacts weakly with human PARP-1.
Immunogen
Recombinant mouse PARP-1 [ARTD1] (aa 215-525).
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Discover our top product PARP1 Primary Antibody
Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
Lot specific
Buffer
Contains 0.1 % sodium azide.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C,-20 °C
Storage Comment
Short Term Storage: +4°C Long Term Storage: -20°C Stable for at least 1 year after receipt when stored at -20°C.
Expiry Date
12 months
Target Details for PARP1
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Target
PARP1
(Poly (ADP-Ribose) Polymerase 1 (PARP1))
Alternative Name
PARP-1 [ARTD1] (PARP1 Products )
Synonyms
ADPRT antibody, ADPRT 1 antibody, ADPRT1 antibody, ARTD1 antibody, PARP antibody, PARP-1 antibody, PPOL antibody, pADPRT-1 antibody, Adprt antibody, Parp-1 antibody, 5830444G22Rik antibody, AI893648 antibody, Adprp antibody, Adprt1 antibody, C80510 antibody, parp-1 antibody, sPARP-1 antibody, BEST:LD21673 antibody, CG17685 antibody, CG17696 antibody, CG17718 antibody, CG40411 antibody, D.PARP antibody, Dm.pARTa antibody, Dmel\\CG40411 antibody, LD21673.3prime antibody, PARP1 antibody, dPARP antibody, parp antibody, adprt1 antibody, padprt-1 antibody, ppol antibody, si:dkey-206f10.3 antibody, wu:fc60f12 antibody, zgc:110092 antibody, poly(ADP-ribose) polymerase 1 antibody, poly (ADP-ribose) polymerase 1 antibody, poly (ADP-ribose) polymerase family, member 1 antibody, Poly-(ADP-ribose) polymerase antibody, poly(ADP-ribose) polymerase 1 L homeolog antibody, PARP1 antibody, Parp1 antibody, Parp antibody, parp1.L antibody, parp1 antibody
Background
PARP-1 (ARTD1) is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. PARP-1 positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. It forms a complex with EEF1A1 and TXK that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.
UniProt
P11103
Pathways
Apoptosis , Caspase Cascade in Apoptosis , DNA Damage Repair , Production of Molecular Mediator of Immune Response , Maintenance of Protein Location
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