EYA4 antibody (N-Term)
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- Target See all EYA4 Antibodies
- EYA4 (Eyes Absent Homolog 4 (EYA4))
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Binding Specificity
- N-Term
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Reactivity
- Human, Rabbit, Guinea Pig, Mouse, Dog, Zebrafish (Danio rerio)
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This EYA4 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- MEDTQDLNEQ SVKKTCPEAD VSEPQNSRSM EMQDLASPHA LVGGSDTPGS
- Predicted Reactivity
- Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Zebrafish: 85%
- Characteristics
- This is a rabbit polyclonal antibody against Eya4. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N-terminal region of Eya4
- Top Product
- Discover our top product EYA4 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 616 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- EYA4 (Eyes Absent Homolog 4 (EYA4))
- Alternative Name
- Eya4 (EYA4 Products)
- Synonyms
- B130023L16Rik antibody, CMD1J antibody, DFNA10 antibody, EYA transcriptional coactivator and phosphatase 4 antibody, Eya4 antibody, EYA4 antibody
- Background
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Eya4 is a tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Eya4 promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. It may be involved in development of the eye.
Alias Symbols: B130023L16Rik
Protein Interaction Partner: Six1, Six2, Eya4,
Protein Size: 616 - Molecular Weight
- 67 kDa
- Gene ID
- 14051
- NCBI Accession
- NM_010167, NP_034297
- UniProt
- Q9Z191
- Pathways
- Sensory Perception of Sound
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