NKX3-1 antibody (Middle Region)
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- Target See all NKX3-1 Antibodies
- NKX3-1 (NK3 Homeobox 1 (NKX3-1))
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Binding Specificity
- Middle Region
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Reactivity
- Mouse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This NKX3-1 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- TPTEPESDAH FETYLLDCEH NPGDLASAPQ VTKQPQKRSR AAFSHTQVIE
- Predicted Reactivity
- Mouse: 100%
- Characteristics
- This is a rabbit polyclonal antibody against Nkx3-1. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of Mouse Nkx3-1
- Top Product
- Discover our top product NKX3-1 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 237 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- NKX3-1 (NK3 Homeobox 1 (NKX3-1))
- Alternative Name
- Nkx3-1 (NKX3-1 Products)
- Synonyms
- Xbagpipe antibody, Xbap antibody, bagpipe antibody, koza antibody, nkx3-1 antibody, nkx3.1 antibody, si:ch211-67o1.2 antibody, nkx3a antibody, MGC53041 antibody, MGC97890 antibody, Bax antibody, NKX3.1 antibody, NKX3A antibody, Nkx-3.1 antibody, BAPX2 antibody, NKX3 antibody, NK3 homeobox 1 L homeolog antibody, NK3 homeobox 1 antibody, NK-3 transcription factor, locus 1 (Drosophila) antibody, nkx3-1.L antibody, NKX3-1 antibody, nkx3-1 antibody, Nkx3-1 antibody
- Background
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Nkx3-1 is a transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. It plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Nkx3-1 acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to suppress growth and tumorigenicity of prostate carcinoma cells and plays a role in the formation of minor salivary glands (particularly palatine and lingual glands). It is essential for appropriate differentiation and secretory function of the bulbourethral gland.
Alias Symbols: Bax, NKX3.1, NKX3A, Nkx-3.1, bagpipe
Protein Interaction Partner: Fem1b, SP2,
Protein Size: 237 - Molecular Weight
- 27 kDa
- Gene ID
- 18095
- NCBI Accession
- NM_010921, NP_035051
- UniProt
- P97436
- Pathways
- Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Endopeptidase Activity, Positive Regulation of Response to DNA Damage Stimulus
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