FBXW7 antibody (Middle Region)
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- Target See all FBXW7 Antibodies
- FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))
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Binding Specificity
- Middle Region
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Reactivity
- Human, Mouse, Rat, Dog, Cow, Rabbit, Zebrafish (Danio rerio), Guinea Pig, Horse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This FBXW7 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Sequence
- GIDEPLHIKR RKIIKPGFIH SPWKSAYIRQ HRIDTNWRRG ELKSPKVLKG
- Predicted Reactivity
- Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 93%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 93%
- Characteristics
- This is a rabbit polyclonal antibody against Fbxw7. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of mouse Fbxw7
- Top Product
- Discover our top product FBXW7 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 629 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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NF-κB1 inhibits c-Myc protein degradation through suppression of FBW7 expression." in: Oncotarget, Vol. 5, Issue 2, pp. 493-505, (2014) (PubMed).
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NF-κB1 inhibits c-Myc protein degradation through suppression of FBW7 expression." in: Oncotarget, Vol. 5, Issue 2, pp. 493-505, (2014) (PubMed).
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- Target
- FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))
- Alternative Name
- Fbxw7 (FBXW7 Products)
- Synonyms
- cdc4 antibody, AGO antibody, CDC4 antibody, FBW6 antibody, FBW7 antibody, FBX30 antibody, FBXO30 antibody, FBXW6 antibody, SEL-10 antibody, SEL10 antibody, hAgo antibody, hCdc4 antibody, 1110001A17Rik antibody, Cdc4 antibody, Fbw7 antibody, Fbwd6 antibody, Fbx30 antibody, Fbxo30 antibody, Fbxw6 antibody, F-box and WD repeat domain containing 7 antibody, F-box and WD-40 domain protein 7 antibody, Fbxw7 antibody, FBXW7 antibody, fbxw7 antibody
- Background
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Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.
Alias Symbols: 1110001A17Rik, AGO, Cdc4, Fbw7, Fbwd6, Fbx30, Fbxo30, Fbxw6, SEL-10
Protein Interaction Partner: Skp1a, CREB3L1, CREB3L2, Cul1, Prkcz, Prkce, Prkcd, Prkcb, Prkca, Pten, Mcl1, CEBPA, Pin1, MYB, Npm1, Jun,
Protein Size: 629 - Molecular Weight
- 70 kDa
- Gene ID
- 50754
- NCBI Accession
- NM_080428, NP_536353
- UniProt
- Q8VBV4
- Pathways
- Notch Signaling, EGFR Signaling Pathway
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