ERCC6 antibody (C-Term)

Catalog No. ABIN2780327

Product Details anti-ERCC6 Antibody

Target: ERCC6 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6 (ERCC6))

Binding Specificity: C-Term

Reactivity: Human, Rat, Mouse, Cow, Rabbit, Dog, Guinea Pig, Horse, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERCC6 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: EASALLPTTE HDDLLVEMRN FIAFQAHTDG QASTREILQE FESKLSASQS

Predicted Reactivity: Cow: 86%, Dog: 79%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Mouse: 79%, Rabbit: 79%, Rat: 86%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against ERCC6. It was validated on Western Blot.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C-terminal region of human ERCC6

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeat freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ERCC6

Target: ERCC6 (Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6 (ERCC6))

Alternative Name: ERCC6 (ERCC6 Products)

Synonyms: ARMD5 antibody, CKN2 antibody, COFS antibody, COFS1 antibody, CSB antibody, RAD26 antibody, UVSS1 antibody, 4732403I04 antibody, C130058G22Rik antibody, ercc6 antibody, Ercc6 antibody, ERCC excision repair 6, chromatin remodeling factor antibody, excision repair cross-complementing rodent repair deficiency, complementation group 6 antibody, excision repair cross-complementation group 6 antibody, DNA excision repair protein ERCC-6 antibody, ERCC6 antibody, Ercc6 antibody, ercc6 antibody, LOC100719487 antibody

Background: This gene encodes a DNA-binding protein that is important in transcription-coupled excision repair. The encoded protein has ATP-stimulated ATPase activity, interacts with several transcription and excision repair proteins, and may promote complex formation at DNA repair sites. Mutations in this gene are associated with Cockayne syndrome type B and cerebrooculofacioskeletal syndrome 1. Naturally-occurring readthrough transcription occurs between this gene and the adjacent PGBD3 gene (GeneID:267004), and results in a fusion protein that shares sequence with the product of each individual gene. The readthrough locus is represented by GeneID:101243544.
Alias Symbols: CSB, CKN2, COFS, ARMD5, COFS1, RAD26, UVSS1
Protein Size: 863

Molecular Weight: 94 kDa

Gene ID: 2074

NCBI Accession: NM_000124, NP_000115

UniProt: Q03468

Pathways: DNA Damage Repair, Chromatin Binding