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IL12RB2 antibody (Middle Region)
IL12RB2
Reactivity: Human, Mouse, Rat, Cow, Pig, Dog, Guinea Pig, Horse, Rabbit, Sheep
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-IL12RB2 Antibody
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Target
See all IL12RB2 Antibodies
IL12RB2
(Interleukin 12 Receptor, beta 2 (IL12RB2))
Binding Specificity
All epitopes for IL12RB2 antibodies
Middle Region
Reactivity
Human, Mouse, Rat, Cow, Pig, Dog, Guinea Pig, Horse, Rabbit, Sheep
Host
All hosts for IL12RB2 antibodies
Rabbit
Clonality
All clonalities for IL12RB2 antibodies
Polyclonal
Conjugate
All conjugates for IL12RB2 antibodies
This IL12RB2 antibody is un-conjugated
Application
All applications for IL12RB2 antibodies
Western Blotting (WB)
Sequence
DVWYMKRHID YSRQQISLFW KNLSVSEARG KILHYQVTLQ ELTGGKAMTQ
Predicted Reactivity
Cow: 100%, Dog: 93%, Guinea Pig: 86%, Horse: 86%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 92%, Rat: 100%, Sheep: 100%
Characteristics
This is a rabbit polyclonal antibody against IL12RB2. It was validated on Western Blot.
Purification
Affinity Purified
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of Human IL12RB2
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeat freeze-thaw cycles.
Storage
-20 °C
Storage Comment
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Target Details for IL12RB2
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Target
IL12RB2
(Interleukin 12 Receptor, beta 2 (IL12RB2))
Alternative Name
IL12RB2 (IL12RB2 Products )
Synonyms
IL12RB2 antibody, A930027I18Rik antibody, IL-12RB2 antibody, Ifnm antibody, interleukin 12 receptor subunit beta 2 antibody, interleukin 12 receptor, beta 2 antibody, IL12RB2 antibody, Il12rb2 antibody
Background
The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Protein Interaction Partner: SOCS3, IL12RB2, IL12RB1, STAT4, IL12B, JAK2, Protein Size: 659
Molecular Weight
72 kDa
Gene ID
3595
Pathways
JAK-STAT Signaling
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