EBP antibody (N-Term)
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- Target See all EBP Antibodies
- EBP (Emopamil Binding Protein (Sterol Isomerase) (EBP))
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Binding Specificity
- N-Term
- Reactivity
- Human, Mouse, Rat, Guinea Pig, Pig, Rabbit, Cow, Dog, Horse
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This EBP antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- LVIEGWFVLY YEDLLGDQAF LSQLWKEYAK GDSRYILGDN FTVCMETITA
- Predicted Reactivity
- Cow: 93%, Dog: 93%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 85%, Pig: 93%, Rabbit: 93%, Rat: 85%
- Characteristics
- This is a rabbit polyclonal antibody against EBP. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the N terminal region of human EBP
- Top Product
- Discover our top product EBP Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 230 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- EBP (Emopamil Binding Protein (Sterol Isomerase) (EBP))
- Alternative Name
- EBP (EBP Products)
- Synonyms
- cdpx2 antibody, cho2 antibody, cpx antibody, cpxd antibody, zgc:91895 antibody, CDPX2 antibody, CHO2 antibody, CPX antibody, CPXD antibody, AI255399 antibody, Pabp antibody, Td antibody, mSI antibody, emopamil binding protein (sterol isomerase) antibody, emopamil binding protein (sterol isomerase) L homeolog antibody, phenylalkylamine Ca2+ antagonist (emopamil) binding protein antibody, Ebp antibody, ebp.L antibody, ebp antibody, EBP antibody
- Background
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EBP is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in EBP gene cause Chondrodysplasia punctata 2 (CDPX2, also known as Conradi-Hunermann syndrome).Emopamil-binding protein (EBP) is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. EBP shares structural features with bacterial and eukaryontic drug transporting proteins. It has four putative transmembrane segments and contains two conserved glutamate residues which may be involved in the transport of cationic amphiphilics. Another prominent feature of EBP is its high content of aromatic amino acid residues (>23 % ) in its transmembrane segments. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in this gene cause Chondrodysplasia punctata 2 (CDPX2, also known as Conradi-Hunermann syndrome).
Alias Symbols: CDPX2, CHO2, CPX, CPXD
Protein Interaction Partner: UBC, MITF, VKORC1, APP, ELAVL1, ESRRG, EBPL,
Protein Size: 230 - Molecular Weight
- 26 kDa
- Gene ID
- 10682
- NCBI Accession
- NM_006579, NP_006570
- UniProt
- Q15125
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