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CLK1 antibody (N-Term)

CLK1 Reactivity: Human, Mouse, Horse, Rabbit, Rat, Cow, Dog, Guinea Pig WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN2784736
  • Target See all CLK1 Antibodies
    CLK1 (CDC like Kinase 1 (CLK1))
    Binding Specificity
    • 9
    • 9
    • 7
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 28
    • 27
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Horse, Rabbit, Rat, Cow, Dog, Guinea Pig
    Host
    • 40
    • 2
    Rabbit
    Clonality
    • 42
    Polyclonal
    Conjugate
    • 20
    • 4
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CLK1 antibody is un-conjugated
    Application
    • 34
    • 24
    • 9
    • 7
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Sequence
    HSSAQENKRC KYNHSKMCDS HYLESRSINE KDYHSRRYID EYRNDYTQGC
    Predicted Reactivity
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 86%, Rabbit: 100%, Rat: 85%
    Characteristics
    This is a rabbit polyclonal antibody against CLK1. It was validated on Western Blot.
    Purification
    Affinity Purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the N terminal region of human CLK1
    Top Product
    Discover our top product CLK1 Primary Antibody
  • Application Notes
    Optimal working dilutions should be determined experimentally by the investigator.
    Comment

    Antigen size: 484 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze-thaw cycles.
    Storage
    -20 °C
    Storage Comment
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Aubol, Wu, Keshwani, Movassat, Fattet, Hertel, Fu, Adams: "Release of SR Proteins from CLK1 by SRPK1: A Symbiotic Kinase System for Phosphorylation Control of Pre-mRNA Splicing." in: Molecular cell, Vol. 63, Issue 2, pp. 218-228, (2016) (PubMed).

    Eisenreich, Zakrzewicz, Huber, Thierbach, Pepke, Goldin-Lang, Schultheiss, Pries, Rauch: "Regulation of pro-angiogenic tissue factor expression in hypoxia-induced human lung cancer cells." in: Oncology reports, Vol. 30, Issue 1, pp. 462-70, (2013) (PubMed).

  • Target
    CLK1 (CDC like Kinase 1 (CLK1))
    Alternative Name
    CLK1 (CLK1 Products)
    Synonyms
    CLK antibody, CLK/STY antibody, STY antibody, CDC like kinase 1 antibody, CDC-like kinase 1 antibody, CLK1 antibody, Clk1 antibody
    Background
    This gene encodes a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. In the nucleus, the encoded protein phosphorylates serine/arginine-rich proteins involved in pre-mRNA processing, releasing them into the nucleoplasm. The choice of splice sites during pre-mRNA processing may be regulated by the concentration of transacting factors, including serine/arginine rich proteins. Therefore, the encoded protein may play an indirect role in governing splice site selection. Multiple transcript variants encoding different isoforms have been found for this gene.
    Alias Symbols: CLK, CLK/STY, STY
    Protein Interaction Partner: KRTAP10-7, PDE9A, PRMT5, SRPK2, SRPK1, CLK1, BAG3, PIAS4, ISG15, UBC, YWHAG, LUC7L3, PPIG, SRSF6, PRPF4, GOLM1, UBL5, SRSF1, PTPN1, MBP, BCLAF1, NCOR1, SRSF3, SAFB,
    Protein Size: 484
    Molecular Weight
    57 kDa
    Gene ID
    1195
    NCBI Accession
    NM_004071, NP_004062
    UniProt
    P49759
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