SHC3 antibody (Middle Region)
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- Target See all SHC3 Antibodies
- SHC3 (SHC (Src Homology 2 Domain Containing) Transforming Protein 3 (SHC3))
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Binding Specificity
- Middle Region
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Reactivity
- Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This SHC3 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- RLKPRPHAPD TAQFAGKEQT YYQGRHLGDT FGEDWQQTPL RQGSSDIYST
- Predicted Reactivity
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%
- Characteristics
- This is a rabbit polyclonal antibody against SHC3. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogen
- The immunogen is a synthetic peptide directed towards the middle region of human SHC3
- Top Product
- Discover our top product SHC3 Primary Antibody
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- Application Notes
- Optimal working dilutions should be determined experimentally by the investigator.
- Comment
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Antigen size: 594 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freeze-thaw cycles.
- Storage
- -20 °C
- Storage Comment
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Target
- SHC3 (SHC (Src Homology 2 Domain Containing) Transforming Protein 3 (SHC3))
- Alternative Name
- SHC3 (SHC3 Products)
- Synonyms
- N-Shc antibody, NSHC antibody, RAI antibody, SHCC antibody, ShcC antibody, Rai antibody, SHC adaptor protein 3 antibody, src homology 2 domain-containing transforming protein C3 antibody, SHC3 antibody, Shc3 antibody
- Background
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SHC3 is a signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. SHC3 is involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons.
Alias Symbols: N-Shc, NSHC, SHCC, RAI
Protein Interaction Partner: KRT40, KRT31, GOLGA2, ERBB3, ERBB2, EGFR, SH3GL3, ARHGAP32, NTRK2, NTRK1, RET, FLT4, AXL, GRB2, ALK, APP,
Protein Size: 594 - Molecular Weight
- 64 kDa
- Gene ID
- 53358
- NCBI Accession
- NM_016848, NP_058544
- UniProt
- Q92529
- Pathways
- RTK Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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