PIDD antibody (N-Term)

Catalog No. ABIN2787143

The Rabbit Polyclonal anti-PIDD antibody (ABIN2787143) specifically detects PIDD in WB. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for PIDD antibody (N-Term) (ABIN2787143)

Target: PIDD (P53-Induced Death Domain Protein (PIDD))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PIDD antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PIDD Antibody

Binding Specificity: N-Term

Purpose: PIDD1 Antibody - N-terminal region

Sequence: RLQGNPLGEA SPDAPSSPVA ALIPEMPRLF LTSDLDSFPV TPQGCSVTLA

Predicted Reactivity: Human: 100%, Mouse: 86%, Rat: 100%

Characteristics: This is a rabbit polyclonal antibody against LRDD. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human LRDD

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP57269-100UG

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: prevent freeze-thaw cycles

Storage: 4 °C,-20 °C

Storage Comment: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Target Details for PIDD

Target: PIDD (P53-Induced Death Domain Protein (PIDD))

Alternative Name: PIDD1

Background:

Background Information: The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Alternative splicing results in multiple transcript variants.

Gene Name: p53-induced death domain protein 1

Alternative Symbols: LRDD, PIDD

Protein Name: p53-induced death domain-containing protein 1

Molecular Weight: 83kDa

Gene ID: 55367

NCBI Accession: NP_060964

UniProt: Q9HB75

Pathways: p53 Signaling, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity