ERP44 antibody (Middle Region)

Catalog No. ABIN2787804

Product Details anti-ERP44 Antibody

Target: ERP44 (Endoplasmic Reticulum Protein 44 (ERP44))

Binding Specificity: Middle Region

Reactivity: Human, Mouse, Rat, Cow, Rabbit, Dog, Horse, Guinea Pig, Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ERP44 antibody is un-conjugated

Application: Western Blotting (WB)

Sequence: LHREFHHGPD PTDTAPGEQA QDVASSPPES SFQKLAPSEY RYTLLRDRDE

Predicted Reactivity: Cow: 93%, Dog: 86%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Zebrafish: 79%

Characteristics: This is a rabbit polyclonal antibody against TXNDC4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TXNDC4

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 406 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for ERP44

Target: ERP44 (Endoplasmic Reticulum Protein 44 (ERP44))

Alternative Name: TXNDC4 (ERP44 Products)

Synonyms: PDIA10 antibody, TXNDC4 antibody, 1110001E24Rik antibody, AI849526 antibody, AL033348 antibody, Txndc4 antibody, BWK4 antibody, txndc4 antibody, zgc:77883 antibody, endoplasmic reticulum protein 44 antibody, ERP44 antibody, Erp44 antibody, erp44 antibody

Background: TXNDC4 mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. TXNDC4 inhibits the calcium channel activity of ITPR1. TXNDC4 may have a role in the control of oxidative protein folding in the endoplasmic reticulum. TXNDC4 is required to retain ERO1L and ERO1LB in the endoplasmic reticulum.
Alias Symbols: ERP44, KIAA0573, PDIA10, TXNDC4
Protein Interaction Partner: FUS, UBC, SUMO1, NEDD8, NUDCD1, UBFD1, OSGEP, LARS, ISOC1, PLD3, PDCD10, FERMT2, YWHAZ, VCL, PFAS, PAK2, G6PD, FHL2, CNN2, TBCB, CKB, env, ELAVL1, SUMO4, RASSF5, USP32, USP46, UIMC1, ERO1LB, ERO1L, ITPR1, CD40,
Protein Size: 406

Molecular Weight: 45 kDa

Gene ID: 23071

NCBI Accession: NM_015051, NP_055866

UniProt: Q9BS26

Pathways: Cell RedoxHomeostasis, SARS-CoV-2 Protein Interactome