PAWR antibody

Catalog No. ABIN1944911

Product Details anti-PAWR Antibody

Target: PAWR (PRKC, Apoptosis, WT1, Regulator (PAWR))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAWR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Isotype: IgG

Application Details

Application Notes: WB: 1:1000. WB: 1:1000. IHC: 1:50-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Preservative: Sodium azide

Precaution of Use: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Storage: 4 °C,-20 °C

References for anti-PAWR antibody (ABIN1944911)

Chakraborty, Qiu, Vasudevan, Rangnekar: "Par-4 drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression." in: Cancer research, Vol. 61, Issue 19, pp. 7255-63, (2001) (PubMed).

Chang, Kim, Shin: "p62 forms a ternary complex with PKCzeta and PAR-4 and antagonizes PAR-4-induced PKCzeta inhibition." in: FEBS letters, Vol. 510, Issue 1-2, pp. 57-61, (2001) (PubMed).

Johnstone, See, Sells, Wang, Muthukkumar, Englert, Haber, Licht, Sugrue, Roberts, Rangnekar, Shi: "A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1." in: Molecular and cellular biology, Vol. 16, Issue 12, pp. 6945-56, (1997) (PubMed).

Target Details for PAWR

Target: PAWR (PRKC, Apoptosis, WT1, Regulator (PAWR))

Abstract: PAWR Products

Synonyms: MGC81382 antibody, pawrl antibody, zgc:103513 antibody, PAWR antibody, PAR4 antibody, Par-4 antibody, Par4 antibody, 2310001G03Rik antibody, pro-apoptotic WT1 regulator antibody, PRKC, apoptosis, WT1, regulator L homeolog antibody, PRKC, apoptosis, WT1, regulator antibody, PAWR antibody, pawr.L antibody, pawr antibody, Pawr antibody

Background: Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down- regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.

Molecular Weight: 36568 Da

Gene ID: 5074

UniProt: Q96IZ0