NTRK3 antibody

Catalog No. ABIN2841830

Product Details anti-NTRK3 Antibody

Target: NTRK3 (Neurotrophic tyrosine Kinase, Receptor, Type 3 (NTRK3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NTRK3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This NTRK3 antibody is generated from rabbits immunized with a his tag recombinant protein of human NTRK3.

Clone: RB16731

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for NTRK3

Target: NTRK3 (Neurotrophic tyrosine Kinase, Receptor, Type 3 (NTRK3))

Alternative Name: TrkC (NTRK3 Products)

Synonyms: TRKC antibody, gp145(trkC) antibody, trkC antibody, AW125844 antibody, Ntrk3_tv3 antibody, TrkC antibody, neurotrophic receptor tyrosine kinase 3 antibody, neurotrophic tyrosine kinase, receptor, type 3 antibody, NTRK3 antibody, Ntrk3 antibody

Background: NTRK3, a member of the insuline receptor subfamily of Tyr protein kinases, is a receptor for neurotrophin-3 (NT-3). Known substrates for the NTRK receptors are SHC, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties. The protein is widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain. NTRK3 is subject to ligand-mediated auto-phosphorylation. The protein structure contains 2 immunoglobulin-like C2-type domains and 2 leucine-rich (LRR) repeats.

Molecular Weight: 94428

Gene ID: 4916

NCBI Accession: NP_001012338, NP_002521

UniProt: Q16288

Pathways: RTK Signaling, Neurotrophin Signaling Pathway, Regulation of Cell Size