Osteoactivin antibody
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- Target See all Osteoactivin (GPNMB) Antibodies
- Osteoactivin (GPNMB)
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Osteoactivin antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Cross-Reactivity
- Human
- Characteristics
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Rabbit Polyclonal antibody to GPNMB (glycoprotein (transmembrane) nmb)
GPNMB antibody [N2C2], Internal - Purification
- Purified by antigen-affinity chromatography.
- Immunogen
- Recombinant protein encompassing a sequence within the center region of human GPNMB. The exact sequence is proprietary.
- Isotype
- IgG
- Top Product
- Discover our top product GPNMB Primary Antibody
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- Application Notes
- WB: 1:500-1:3000. IHC-P: 1:100-1:1000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.
- Comment
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Positive Control: SKBR3
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- 1XPBS ( pH 7), 1 % BSA, 20 % Glycerol, 0.01 % Thimerosal
- Preservative
- Thimerosal (Merthiolate)
- Precaution of Use
- This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.
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- Target
- Osteoactivin (GPNMB)
- Alternative Name
- glycoprotein nmb (GPNMB Products)
- Synonyms
- HGFIN antibody, NMB antibody, DC-HIL antibody, Dchil antibody, ipd antibody, glycoprotein nmb antibody, glycoprotein (transmembrane) nmb antibody, glycoprotein nmb L homeolog antibody, Gpnmb antibody, GPNMB antibody, gpnmb.L antibody
- Background
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The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene.
Cellular Localization: Membrane, Single-pass type I membrane protein (Potential) , Melanosome - Molecular Weight
- 64 kDa
- Gene ID
- 10457
- UniProt
- Q14956
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