TRKA antibody (Extracellular Domain)

Catalog No. ABIN285990

Product Details anti-TRKA Antibody

Target: TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))

Binding Specificity: Extracellular Domain

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TRKA antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Cross-Reactivity: Human, Mouse (Murine)

Cross-Reactivity (Details): Reacts with Rat, Mouse and Human. Reactivity to other species is unknown. Recognizes TrkA, Mr 140 kDa. Does not crossreact with TrkB or TrkC.

Purification: Protein A affinity chromatography

Immunogen: TrkA antibody was raised in rabbit using recombinant protein corresponding to extracellular domain of rat TrkA receptor as the immunogen.

Isotype: IgG

Application Details

Application Notes: Optimal conditions should be determined byt he investigator.

Restrictions: For Research Use only

Handling

Concentration: Lot specific

Buffer: 20 mM PO4 buffer, pH 7.6, with 250 M NaCl and 0.1 % NaN3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Storage: -20 °C

Storage Comment: Aliquot and store at -20 °C.

Target Details for TRKA

Target: TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))

Alternative Name: TrkA (NTRK1 Products)

Synonyms: MTC antibody, TRK antibody, TRK1 antibody, TRKA antibody, Trk-A antibody, p140-TrkA antibody, CDHF12 antibody, CDHR16 antibody, HSCR1 antibody, MEN2A antibody, MEN2B antibody, MTC1 antibody, PTC antibody, RET-ELE1 antibody, RET51 antibody, Trk antibody, C80751 antibody, Tkr antibody, TrkA antibody, trk antibody, trka antibody, CTRKA antibody, trkA antibody, neurotrophic receptor tyrosine kinase 1 antibody, ret proto-oncogene antibody, neurotrophic tyrosine kinase, receptor, type 1 antibody, NTRK1 antibody, RET antibody, Ntrk1 antibody, ntrk1 antibody

Background: TrkA, apparent molecular weight 140 kDa, is a high affinity nerve growth factor (NGF). The Trk proto-oncogene family contains four members, TrkA, Tr kb, TrkC, and TrkE, which are variably expressed throughout the central and peripheral nervous systems. TrkA binds to nerve growth factor (NGF) and autophosphorylates on tyrosine residues (Tyr490, Tyr674, Tyr675, Tyr751 and Tyr785) to activate multiple downstream effector proteins.

Molecular Weight: 140 kDa (predicted detection band MW)

Pathways: RTK Signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process