SGK1 antibody (AA 172-431)

Catalog No. ABIN3021291

Product Details anti-SGK1 Antibody

Target: SGK1 (serum/glucocorticoid Regulated Kinase 1 (SGK1))

Binding Specificity: AA 172-431

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SGK1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Sequence: LYFVLDYING GELFYHLQRE RCFLEPRARF YAAEIASALG YLHSLNIVYR DLKPENILLD SQGHIVLTDF GLCKENIEHN STTSTFCGTP EYLAPEVLHK QPYDRTVDWW CLGAVLYEML YGLPPFYSRN TAEMYDNILN KPLQLKPNIT NSARHLLEGL LQKDRTKRLG AKDDFMEIKS HVFFSLINWD DLINKKITPP FNPNVSGPND LRHFDPEFTE EPVPNSIGKS PDSVLVTASV KEAAEAFLGF SYAPPTDSFL

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 172-431 of human SGK1 (NP_005618.2).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

References for anti-SGK1 antibody (ABIN3021291)

Li, Zhou, Yang, Li, Zhang, Wang, Jiao: "SGK1 inhibits PM2.5-induced apoptosis and oxidative stress in human lung alveolar epithelial A549 cells." in: Biochemical and biophysical research communications, Vol. 496, Issue 4, pp. 1291-1295, (2018) (PubMed).

"Retracted: 'Anti-fibrotic actions of Ghrelin by inhibition of the NADPH oxidase-ROS signaling pathway' by Qian Wang, Xin Sui, Rui Chen, Peiyong Ma, Tao Ding, Dianjun Sui, and Ping Yang." in: Clinical and experimental pharmacology & physiology, Vol. 45, Issue 8, pp. 885, (2018) (PubMed).

Target Details for SGK1

Target: SGK1 (serum/glucocorticoid Regulated Kinase 1 (SGK1))

Alternative Name: SGK1 (SGK1 Products)

Synonyms: SGK antibody, Sgk antibody, sgk-B antibody, sgk2 antibody, cb1083 antibody, sgk antibody, wu:fc20a09 antibody, sgk-A antibody, sgk1 antibody, sgk1-a antibody, sgk1-b antibody, serum/glucocorticoid regulated kinase 1 antibody, Serine/threonine-protein kinase sgk-1 antibody, serum/glucocorticoid regulated kinase 1 S homeolog antibody, serum/glucocorticoid regulated kinase 1 L homeolog antibody, SGK1 antibody, Sgk1 antibody, sgk-1 antibody, sgk1.S antibody, sgk1 antibody, sgk1.L antibody

Background: This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.,SGK1,SGK,Signal Transduction,Kinase,Serine/threonine kinases,mTOR Signaling Pathway,Cell Biology & Developmental Biology,Apoptosis,Endocrine & Metabolism,Insulin Receptor Signaling Pathway,Stem Cells,Embryonic Stem Cells,SGK1

Molecular Weight: 47 kDa/48 kDa/50 kDa/52 kDa/59 kDa

Gene ID: 6446

UniProt: O00141

Pathways: MAPK Signaling, Notch Signaling, Steroid Hormone Mediated Signaling Pathway