P2RX2 antibody (AA 139-471)

Catalog No. ABIN3032407

Product Details anti-P2RX2 Antibody

Target: P2RX2 (Purinergic Receptor P2X, Ligand Gated Ion Channel 2 (P2RX2))

Binding Specificity: AA 139-471

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This P2RX2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: Antigen affinity

Immunogen: Human partial recombinant protein (AA 139-471) was used as the immunogen for this P2X2 antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the P2X2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 0.5-1 μg/mL,IHC (Paraffin): 0.5-1 μg/mL

Restrictions: For Research Use only

Handling

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: -20 °C

Storage Comment: After reconstitution, the P2X2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Target Details for P2RX2

Target: P2RX2 (Purinergic Receptor P2X, Ligand Gated Ion Channel 2 (P2RX2))

Alternative Name: P2X2 (P2RX2 Products)

Synonyms: DFNA41 antibody, P2X2 antibody, P2X2a antibody, P2x2 antibody, p2xr2 antibody, P2RX2 antibody, purinergic receptor P2X 2 antibody, purinergic receptor P2X, ligand-gated ion channel, 2 antibody, P2RX2 antibody, P2rx2 antibody, p2rx2 antibody

Background: The P2RX2 gene encodes the P2X2 receptor, which assembles as a trimer to form a ligand-gated ion channel gated by extracellular ATP. P2X2 receptors mediate a variety of cellular responses, including excitatory postsynaptic responses in sensory neurons. The product of this gene belongs to the family of purinoceptors for ATP. P2RX2 is mapped to 12q24.33. It has been found that ATP-activated P2RX2 influenced OHC electromotility, a stimulus-induced change in hair cell length that functions as an amplifier to determine hearing sensitivity and frequency selectivity. Additionally, P2RX2 channels were necessary for development of the temporary threshold shift.

Gene ID: 22953

Pathways: Skeletal Muscle Fiber Development, Positive Regulation of Endopeptidase Activity