PPP3CA antibody (C-Term)
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- Target See all PPP3CA Antibodies
- PPP3CA (Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA))
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Binding Specificity
- AA 488-521, C-Term
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This PPP3CA antibody is un-conjugated
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Application
- Western Blotting (WB)
- Purpose
- Rabbit IgG polyclonal antibody for Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform(PPP3CA) detection. Tested with WB in Human.
- Sequence
- DAMPSDANLN SINKALTSET NGTDSNGSNS SNIQ
- Cross-Reactivity (Details)
- No cross reactivity with other proteins.
- Characteristics
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Rabbit IgG polyclonal antibody for Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform(PPP3CA) detection. Tested with WB in Human.
Gene Name: protein phosphatase 3, catalytic subunit, alpha isozyme
Protein Name: Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform - Purification
- Immunogen affinity purified.
- Immunogen
- A synthetic peptide corresponding to a sequence at the C-terminus of human Calcineurin A (488-521aa DAMPSDANLNSINKALTSETNGTDSNGSNSSNIQ), different from the related mouse and rat sequences by one amino acid.
- Isotype
- IgG
- Top Product
- Discover our top product PPP3CA Primary Antibody
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- Application Notes
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WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users. - Comment
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- Concentration
- 500 μg/mL
- Buffer
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
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At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
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Buckwheat Rutin Inhibits AngII-induced Cardiomyocyte Hypertrophy via Blockade of CaN-dependent Signal Pathway." in: Iranian journal of pharmaceutical research : IJPR, Vol. 13, Issue 4, pp. 1347-55, (2015) (PubMed).
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Buckwheat Rutin Inhibits AngII-induced Cardiomyocyte Hypertrophy via Blockade of CaN-dependent Signal Pathway." in: Iranian journal of pharmaceutical research : IJPR, Vol. 13, Issue 4, pp. 1347-55, (2015) (PubMed).
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- Target
- PPP3CA (Protein Phosphatase 3, Catalytic Subunit, alpha Isoform (PPP3CA))
- Alternative Name
- PPP3CA (PPP3CA Products)
- Background
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Calcineurin A is also known as PPP3CA. It is mapped to 4q24. Semsarian et al. (1999) and Musaro et al. (1999) independently showed that IGF1stimulates skeletal muscle hypertrophy and a switch to glycolytic metabolism by activating calcineurin A and inducing the nuclear translocation of transcription factor NFATC1. Semsarian et al. (1999) found that hypertrophy was suppressed by the calcineurin inhibitors cyclosporin A or FK506, but not by inhibitors of the MAP kinase or phosphatidylinositol-3-OH kinase pathways. Musaro et al. (1999) showed that expression of a dominant-negative calcineurin mutant also repressed myocyte differentiation and hypertrophy. Musaro et al. (1999) demonstrated that either IGF1 or activated calcineurin induces expression of transcription factor GATA2, which accumulates in a subset of myocyte nuclei, where it associates with calcineurin and a specific dephosphorylated isoform of NFATC1.
Synonyms: Alpha isoform formerly PPP2B antibody|Calcineurin A alpha antibody|Calcineurin A1 antibody|CalcineurinA antibody|Calmodulin dependent calcineurin A subunit alpha isoform antibody|Calmodulin-dependent calcineurin A subunit alpha isoform antibody|CALN antibody|CALNA 1 antibody|CALNA antibody|CALNA1 antibody|CAM PRP catalytic subunit antibody|CAM-PRP catalytic subunit antibody|CCN 1 antibody|CCN1 antibody|CNA 1 antibody|CNA alpha antibody|CNA antibody|CNA1 antibody|FLJ26613 antibody|MGC52248 antibody|PP2BA_HUMAN antibody|PPP2B antibody|PPP3CA antibody|Protein phosphatase 2B catalytic subunit antibody|Protein phosphatase 3 (formerly 2B) catalytic subunit alpha isoform antibody|Protein phosphatase 3 catalytic subunit alpha isoform PPP3CA antibody|Protein phosphatase 3 catalytic subunit alpha isozyme antibody|Serine/threonine protein phosphatase 2B catalytic subunit alpha isoform antibody|Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform antibody - Gene ID
- 5530
- UniProt
- Q08209
- Pathways
- RTK Signaling, WNT Signaling, Fc-epsilon Receptor Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Synaptic Membrane, Skeletal Muscle Fiber Development, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling
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