ERBB4 antibody (N-Term)
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- Target See all ERBB4 Antibodies
- ERBB4 (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4))
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Binding Specificity
- AA 35-51, N-Term
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This ERBB4 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Purpose
- Rabbit IgG polyclonal antibody for Receptor tyrosine-protein kinase erbB-4(ERBB4) detection. Tested with WB in Human,Mouse,Rat.
- Sequence
- KLSSLSDLEQ QYRALRK
- Cross-Reactivity (Details)
- No cross reactivity with other proteins.
- Characteristics
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Rabbit IgG polyclonal antibody for Receptor tyrosine-protein kinase erbB-4(ERBB4) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: v-erb-a erythroblastic leukemia viral oncogene homolog 4(avian)
Protein Name: Receptor tyrosine-protein kinase erbB-4 - Purification
- Immunogen affinity purified.
- Immunogen
- A synthetic peptide corresponding to a sequence at the N-terminus of human ErbB 4(35-51aa KLSSLSDLEQQYRALRK), identical to the related rat and mouse sequences.
- Isotype
- IgG
- Top Product
- Discover our top product ERBB4 Primary Antibody
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- Application Notes
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WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Mouse, Rat, The detection limit for ERBB4 is approximately 0.5 ng/lane under reducing conditions.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users. - Comment
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
- Concentration
- 500 μg/mL
- Buffer
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
- Preservative
- Thimerosal (Merthiolate), Sodium azide
- Precaution of Use
- This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
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At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing. - Expiry Date
- 12 months
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- Target
- ERBB4 (V-Erb-A erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) (ERBB4))
- Alternative Name
- ERBB4 (ERBB4 Products)
- Synonyms
- erbb4 antibody, si:ch211-227n20.1 antibody, Her4 antibody, c-erbB-4 antibody, HER4 antibody, p180erbB4 antibody, erb-b2 receptor tyrosine kinase 4 antibody, erb-b2 receptor tyrosine kinase 4a antibody, v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) antibody, erb-b2 receptor tyrosine kinase 4 L homeolog antibody, receptor tyrosine-protein kinase ErbB-4 antibody, ERBB4 antibody, erbb4a antibody, erbb4 antibody, erbb4.L antibody, Tsp_13582 antibody, Erbb4 antibody
- Background
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ERBB4(V-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4) also known as ONCOGENE ERBB4 or HER4, is an enzyme that in humans is encoded by the ERBB4 gene. The HER4/ERBB4 gene is a member of the type I receptor tyrosine kinase subfamily that includes EGFR, ERBB2 and ERBB3. The ERBB4 gene is mapped on 2q34. ERBB4 is a single-pass type I transmembrane protein with multiple furin-like cysteine rich domains, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domainbinding motif. Huang et al.(2000) reported that ERBB4 is enriched in the postsynaptic density and associates with PSD95. ERBB4 is a transmembrane receptor tyrosine kinase that regulates cell proliferation and differentiation. After binding its ligand, heregulin, or activation of protein kinase C by TPA, the ERBB4 ectodomain is cleaved by a metalloprotease. Ni et al.(2001)concluded that gamma-secretase cleavage of ERBB4 may represent another mechanism for receptor tyrosine kinase-mediated signaling.
Synonyms: 4ICD antibody|Avian erythroblastic leukemia viral oncogene homolog 4 antibody|Avian erythroblastic leukemia viral v erb b2 oncogene homolog 4 antibody|E4ICD antibody|EC 2.7.10.1 antibody|ErbB4 antibody|ERBB4 intracellular domain antibody|ERBB4_HUMAN antibody|HER 4 antibody|HER4 antibody|Mer4 antibody|MGC138404 antibody|Oncogene ERBB4 antibody|P180erbB4 antibody|Proto-oncogene-like protein c-ErbB-4 antibody|Receptor protein tyrosine kinase erbB 4 precursor antibody|Receptor tyrosine protein kinase erbB 4 antibody|s80HER4 antibody|Tyrosine kinase type cell surface receptor HER4 antibody|Tyrosine kinase-type cell surface receptor HER4 antibody|v erb a avian erythroblastic leukemia viral oncogene homolog like 4 antibody|v erb a erythroblastic leukemia viral oncogene homolog 4 antibody|v-erb-a erythroblastic leukemia viral oncogene homolog 4(avian) antibody|V-ERB-B2 avian erythroblastic leukemia viral oncogene homolog 4 antibody|Verba avian erythroblastic leukemia viral oncogene homolog like 4 antibody|Verba erythroblastic leukemia viral oncogene homolog 4 antibody|VERBB2 antibody - UniProt
- Q15303
- Pathways
- RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
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