FBXW7 antibody

Catalog No. ABIN307140

The Rabbit Polyclonal anti-FBXW7 antibody (ABIN307140) specifically detects FBXW7 in WB. The antibody is reactive with Human samples.

Quick Overview for FBXW7 antibody (ABIN307140)

Target: FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXW7 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FBXW7 Antibody

Purpose: Rabbit anti Human FBXW7

Cross-Reactivity: Human

Characteristics: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.

Purification: Ammonium Sulfate Precipitation

Immunogen: Synthetic peptide dervied from the human FBXW7 protein

Application Details

Application Notes: Antibody can be used for Western blotting (1-5 μg/mL). Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: phosphate buffered saline with 0.08 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Target Details for FBXW7

Target: FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

Alternative Name: FBXW7

Background: F-box and WD-40 domain protein 7, FBXW7, CDC4

UniProt: Q969H0

Pathways: Notch Signaling, EGFR Signaling Pathway