ELISA: 1/5000-1/10000. Western Blot: 1/500-1/1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Concentration
1.0 mg/mL
Buffer
PBS, pH ~7.2, 0.05 % Sodium Azide
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target
Endothelin-1 Receptor (EDNRA)
(Endothelin Receptor Type A (EDNRA))
ET-A antibody, ETA antibody, ETA-R antibody, ETAR antibody, ETRA antibody, hET-AR antibody, ET-AR antibody, Endor antibody, Eta antibody, RGD1559432 antibody, ETa antibody, Gpcr10 antibody, ednr-a antibody, ednra antibody, wu:fb75g12 antibody, ednraa antibody, eta antibody, etar antibody, etra antibody, zgc:85942 antibody, endothelin receptor type A antibody, endothelin receptor type Aa antibody, endothelin receptor type A L homeolog antibody, endothelin receptor type Ab antibody, EDNRA antibody, Ednra antibody, ednraa antibody, ednra.L antibody, ednra antibody, ednrab antibody
Background
Endothelin receptor A (ETAR), also known as EDNRA, ET1 receptor, ETA, EDN1 and ET-AR, is a member of the guanine-binding regulatory protein-coupled receptor family. ETAR binds endothelins and has the highest affinity for its ligand, ET1, as compared to the ETBR receptor. Both ET receptors, ETAR and ETBR, are activated by ET1, which results in inhibition of active lens sodiumpotassium transport. Activation of the ET receptors also causes an increase in cytoplasmic calcium concentration in cultured lens epithelial cells. In addition, ETAR induces arachidonic acid accumulation. ETAR has seven hydrophobic transmembrane domains and is expressed in aorta, lung, atrium, kidney, placenta and prostate. Specifically, placental vascular smooth muscle cells (PVSMCs) exclusively express ETAR.Synonyms: EDNRA, ET-A, ETA, ETA-R, ETRA, Endothelin-1 receptor, endothelin receptor type A, hET-AR